Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects

Laura Soldati, Simona Bertoli, Annalisa Terranegra, Caterina Brasacchio, Alessandra Mingione, Elena Dogliotti, Benedetta Raspini, Alessandro Leone, Francesca Frau, Laila Vignati, Angela Spadafranca, Giuseppe Vezzoli, Daniele Cusi, Alberto Battezzati

Research output: Contribution to journalArticle

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Abstract

Background: Nephrolithiasis is more frequent and severe in obese patients from different western nations. This may be supported by higher calcium, urate, oxalate excretion in obese stone formers. Except these parameters, clinical characteristics of obese stone formers were not extensively explored.Aims: In the present paper we studied the relationship between obesity and its metabolic correlates and nephrolithiasis.Materials and methods: We studied 478 Caucasian subjects having BMI ≥ 25 kg/m2. The presence of nephrolithiasis, hypertension, diabetes mellitus and metabolic syndrome were noted. They underwent measurements of anthropometry (BMI and waist circumference, body composition), serum variables (fasting glucose, serum lipids and serum enzymes) and Mediterranean diet (MedDiet) nutritional questionnaire.Results: 45 (9.4%) participants were stone formers. Subjects with high serum concentrations of triglycerides (≥150 mg/dl), fasting glucose (> 100 mg/dl) and AST (>30 U/I in F or >40 U/I in M) were more frequent among stone formers than non-stone formers.Multinomial logistic regression confirmed that kidney stone production was associated with high fasting glucose (OR = 2.6, 95% CI 1.2-5.2, P = 0.011), AST (OR = 4.3, 95% CI 1.1-16.7, P = 0.033) and triglycerides (OR = 2.7, 95% CI 1.3-5.7, P = 0.01).MedDiet score was not different in stone formers and non-stone formers. However, stone formers had a lower consumption frequency of olive oil and nuts, and higher consumption frequency of wine compared with non-stone formers.Conclusions: Overweight and obese stone formers may have a defect in glucose metabolism and a potential liver damage. Some foods typical of Mediterranean diet may protect against nephrolithiasis.

Original languageEnglish
Article number34
JournalJournal of Translational Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - 6 Feb 2014
Externally publishedYes

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Mediterranean Diet
Nephrolithiasis
Nutrition
Metabolism
Glucose
Fasting
Serum
Triglycerides
Anthropometry
Calcium Oxalate
Nuts
Kidney Calculi
Wine
Oxalates
Waist Circumference
Medical problems
Body Composition
Uric Acid
Liver
Logistics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects. / Soldati, Laura; Bertoli, Simona; Terranegra, Annalisa; Brasacchio, Caterina; Mingione, Alessandra; Dogliotti, Elena; Raspini, Benedetta; Leone, Alessandro; Frau, Francesca; Vignati, Laila; Spadafranca, Angela; Vezzoli, Giuseppe; Cusi, Daniele; Battezzati, Alberto.

In: Journal of Translational Medicine, Vol. 12, No. 1, 34, 06.02.2014.

Research output: Contribution to journalArticle

Soldati, L, Bertoli, S, Terranegra, A, Brasacchio, C, Mingione, A, Dogliotti, E, Raspini, B, Leone, A, Frau, F, Vignati, L, Spadafranca, A, Vezzoli, G, Cusi, D & Battezzati, A 2014, 'Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects', Journal of Translational Medicine, vol. 12, no. 1, 34. https://doi.org/10.1186/1479-5876-12-34
Soldati, Laura ; Bertoli, Simona ; Terranegra, Annalisa ; Brasacchio, Caterina ; Mingione, Alessandra ; Dogliotti, Elena ; Raspini, Benedetta ; Leone, Alessandro ; Frau, Francesca ; Vignati, Laila ; Spadafranca, Angela ; Vezzoli, Giuseppe ; Cusi, Daniele ; Battezzati, Alberto. / Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects. In: Journal of Translational Medicine. 2014 ; Vol. 12, No. 1.
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AU - Bertoli, Simona

AU - Terranegra, Annalisa

AU - Brasacchio, Caterina

AU - Mingione, Alessandra

AU - Dogliotti, Elena

AU - Raspini, Benedetta

AU - Leone, Alessandro

AU - Frau, Francesca

AU - Vignati, Laila

AU - Spadafranca, Angela

AU - Vezzoli, Giuseppe

AU - Cusi, Daniele

AU - Battezzati, Alberto

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