Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1

Christoph Peter, Michaela Waibel, Hildegard Keppeler, Rainer Lehmann, Guowang Xu, Anna Halama, Jerzy Adamski, Klaus Schulze-Osthoff, Sebastian Wesselborg, Kirsten Lauber

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24 Citations (Scopus)

Abstract

Efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. A major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (LPC). So far, however, the mechanisms underlying LPC release are poorly understood. In this study, we demonstrate that pharmacological inhibition and RNAi-mediated knock-down of the lipid transporter ABCA1 in apoptotic cells completely abolished phagocyte attraction. Moreover, ectopic expression of ABCA1 significantly enhanced monocyte migration to supernatants of apoptotic cells. Hence, ABCA1 represents a novel regulator of LPC release during apoptosis.

Original languageEnglish
Pages (from-to)568-573
Number of pages6
JournalAutoimmunity
Volume45
Issue number8
DOIs
Publication statusPublished - 1 Dec 2012

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Keywords

  • 'find-me' signal
  • ATP-binding cassette transporter
  • Apoptosis
  • Chemotaxis
  • Lysophosphatidylcholine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Peter, C., Waibel, M., Keppeler, H., Lehmann, R., Xu, G., Halama, A., Adamski, J., Schulze-Osthoff, K., Wesselborg, S., & Lauber, K. (2012). Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1. Autoimmunity, 45(8), 568-573. https://doi.org/10.3109/08916934.2012.719947