Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma

Rakesh K. Gupta, Mohammad Haris, Nuzhat Husain, Mazhar Husain, Kashi N. Prasad, Mohan Pauliah, Chhitiz Srivastava, Mukesh Tripathi, Manu Rastogi, Sanjay Behari, Anup Singh, Divya Rathore, Ram Kishore S Rathore

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology. METHODS: We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging. RESULTS: Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001). CONCLUSIONS: Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume31
Issue number3
DOIs
Publication statusPublished - May 2007
Externally publishedYes

Fingerprint

Tuberculoma
Brain
Vascular Endothelial Growth Factor A
Magnetic Resonance Imaging
Cerebral Blood Volume
Perfusion

Keywords

  • Angiogenesis
  • Brain
  • Microvascular density
  • Perfusion MRI
  • Tuberculoma
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma. / Gupta, Rakesh K.; Haris, Mohammad; Husain, Nuzhat; Husain, Mazhar; Prasad, Kashi N.; Pauliah, Mohan; Srivastava, Chhitiz; Tripathi, Mukesh; Rastogi, Manu; Behari, Sanjay; Singh, Anup; Rathore, Divya; Rathore, Ram Kishore S.

In: Journal of Computer Assisted Tomography, Vol. 31, No. 3, 05.2007, p. 335-341.

Research output: Contribution to journalArticle

Gupta, RK, Haris, M, Husain, N, Husain, M, Prasad, KN, Pauliah, M, Srivastava, C, Tripathi, M, Rastogi, M, Behari, S, Singh, A, Rathore, D & Rathore, RKS 2007, 'Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma', Journal of Computer Assisted Tomography, vol. 31, no. 3, pp. 335-341. https://doi.org/10.1097/01.rct.0000243443.10739.16
Gupta, Rakesh K. ; Haris, Mohammad ; Husain, Nuzhat ; Husain, Mazhar ; Prasad, Kashi N. ; Pauliah, Mohan ; Srivastava, Chhitiz ; Tripathi, Mukesh ; Rastogi, Manu ; Behari, Sanjay ; Singh, Anup ; Rathore, Divya ; Rathore, Ram Kishore S. / Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma. In: Journal of Computer Assisted Tomography. 2007 ; Vol. 31, No. 3. pp. 335-341.
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AU - Haris, Mohammad

AU - Husain, Nuzhat

AU - Husain, Mazhar

AU - Prasad, Kashi N.

AU - Pauliah, Mohan

AU - Srivastava, Chhitiz

AU - Tripathi, Mukesh

AU - Rastogi, Manu

AU - Behari, Sanjay

AU - Singh, Anup

AU - Rathore, Divya

AU - Rathore, Ram Kishore S

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AB - OBJECTIVE: The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology. METHODS: We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging. RESULTS: Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001). CONCLUSIONS: Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future.

KW - Angiogenesis

KW - Brain

KW - Microvascular density

KW - Perfusion MRI

KW - Tuberculoma

KW - Vascular endothelial growth factor

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