Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma

Rakesh K. Gupta, Mohammad Haris, Nuzhat Husain, Mazhar Husain, Kashi N. Prasad, Mohan Pauliah, Chhitiz Srivastava, Mukesh Tripathi, Manu Rastogi, Sanjay Behari, Anup Singh, Divya Rathore, Ram Kishore S. Rathore

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20 Citations (Scopus)


OBJECTIVE: The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology. METHODS: We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging. RESULTS: Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001). CONCLUSIONS: Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalJournal of Computer Assisted Tomography
Issue number3
Publication statusPublished - 1 May 2007



  • Angiogenesis
  • Brain
  • Microvascular density
  • Perfusion MRI
  • Tuberculoma
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gupta, R. K., Haris, M., Husain, N., Husain, M., Prasad, K. N., Pauliah, M., Srivastava, C., Tripathi, M., Rastogi, M., Behari, S., Singh, A., Rathore, D., & Rathore, R. K. S. (2007). Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma. Journal of Computer Assisted Tomography, 31(3), 335-341.