Relationships between haemostatic factors and capillary morphology in human diabetic neuropathy

I. Ford, Rayaz Malik, P. G. Newrick, F. E. Preston, J. D. Ward, M. Greaves

Research output: Contribution to journalArticle

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Abstract

We have examined haemostatic factors in 15 diabetic patients with peripheral neuropathy and 10 diabetic patients without clinical complications. Plasma and blood viscosity, fibrinogen, factor VIIIc, von Willebrand factor activity, spontaneous platelet aggregation and fibrinolytic activity were not significantly different between diabetic patients without clinical complications and diabetic patients with peripheral neuropathy. Platelet aggregation was enhanced in diabetic patients with neuropathy compared with those without complications. In the 15 patients with neuropathy and 3 without complications, who underwent biopsy of sural nerve, skin and muscle, associations were found between haemostatic variables and measures of nerve capillary pathology, notably: plasma fibrinogen and nerve capillary basement membrane thickness (r=0.70, p<0.001); thromboxane B2 production and nerve capillary basement membrane thickness (r=-0.61, p<0.01); plasma fibrinolytic activity and endoneurial capillary lumen size (r=0.60, p<0.01) and endothelial cell outer perimeter (r=0.65, p<0.01). The main associations of skin and muscle capillary abnormalities were with measures of in vitro platelet aggregation, and the correlations found with nerve capillary measurements were not echoed in the overlying muscle and skin. The results are supportive of the involvement of haemostatic abnormalities in the pathogenesis of diabetic neuropathy.

Original languageEnglish
Pages (from-to)628-633
Number of pages6
JournalThrombosis and Haemostasis
Volume68
Issue number6
Publication statusPublished - 1992
Externally publishedYes

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Diabetic Neuropathies
Hemostatics
Peripheral Nervous System Diseases
Platelet Aggregation
Basement Membrane
Muscles
Fibrinogen
Skin
Thromboxane B2
Sural Nerve
Blood Viscosity
von Willebrand Factor
Diabetes Complications
Endothelial Cells
Pathology
Biopsy

ASJC Scopus subject areas

  • Hematology

Cite this

Ford, I., Malik, R., Newrick, P. G., Preston, F. E., Ward, J. D., & Greaves, M. (1992). Relationships between haemostatic factors and capillary morphology in human diabetic neuropathy. Thrombosis and Haemostasis, 68(6), 628-633.

Relationships between haemostatic factors and capillary morphology in human diabetic neuropathy. / Ford, I.; Malik, Rayaz; Newrick, P. G.; Preston, F. E.; Ward, J. D.; Greaves, M.

In: Thrombosis and Haemostasis, Vol. 68, No. 6, 1992, p. 628-633.

Research output: Contribution to journalArticle

Ford, I, Malik, R, Newrick, PG, Preston, FE, Ward, JD & Greaves, M 1992, 'Relationships between haemostatic factors and capillary morphology in human diabetic neuropathy', Thrombosis and Haemostasis, vol. 68, no. 6, pp. 628-633.
Ford, I. ; Malik, Rayaz ; Newrick, P. G. ; Preston, F. E. ; Ward, J. D. ; Greaves, M. / Relationships between haemostatic factors and capillary morphology in human diabetic neuropathy. In: Thrombosis and Haemostasis. 1992 ; Vol. 68, No. 6. pp. 628-633.
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