Regulation of human mixed lymphocyte culture reactions

augmentation of proliferation and generation of cytotoxic cells

Manikkam Suthanthiran, M. Lagman, A. L. Rubin, K. H. Stenzel, A. Novogrodsky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The in vitro proliferation and generation of cytotoxic cells in the mixed lymphocyte culture reaction (MLC) are thought to mimic in vivo cellular immune effector mechanisms operative in allograft rejection. Recent studies have clarified the need for disparity at the D-locus-determined antigens between the stimulator and responder cell populations in the allogeneic MLC reactions. However, very little is known about the initial cell surface interactions of transmembrane propagation of stimulatory signals in the MLC. Since alterations in cell shape or surface architecture could conceivably influence these processes and since the microtubular apparatus is the prime candidate for a cell surface modulating structure, we studied the effect of colchicine (Col), a microtubule disrupting alkaloid, on the allogeneic MLC.

Original languageEnglish
Pages (from-to)923-925
Number of pages3
JournalTransplantation Proceedings
Volume10
Issue number4
Publication statusPublished - 1 Dec 1978
Externally publishedYes

Fingerprint

Mixed Lymphocyte Culture Test
Cell Shape
Colchicine
Alkaloids
Cell Communication
Microtubules
Allografts
Antigens
Population

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Regulation of human mixed lymphocyte culture reactions : augmentation of proliferation and generation of cytotoxic cells. / Suthanthiran, Manikkam; Lagman, M.; Rubin, A. L.; Stenzel, K. H.; Novogrodsky, A.

In: Transplantation Proceedings, Vol. 10, No. 4, 01.12.1978, p. 923-925.

Research output: Contribution to journalArticle

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