Regulation of gene expression in oncogenically transformed cells.

M. Dehbi, P. A. Bédard

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Several genes expressed in response to growth factors are also regulated aberrantly in oncogenically transformed cells. The constitutive expression of genes encoding extracellular proteases, transcription factors, and cytokines is often correlated with cell transformation. In several instances, the uncontrolled expression of these genes is the result of transcriptional activation. Therefore, much attention has been devoted to the study of promoter function in transformed cells. We now review the results of recent investigations on transformation-dependent gene expression. The activation of several transcription factors in oncogenically-transformed cells is described. Results regarding the regulation of promoters through PRD II/kappa B are presented for cells transformed by a variety of oncogenes. Finally, we discuss the significance of transcription factor activation in the process of cell transformation.

Original languageEnglish
Pages (from-to)980-997
Number of pages18
JournalBiochemistry and cell biology = Biochimie et biologie cellulaire
Volume70
Issue number10-11
DOIs
Publication statusPublished - 1 Jan 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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