Regulation of gene expression in oncogenically transformed cells.

Mohammed Dehbi, P. A. Bédard

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Several genes expressed in response to growth factors are also regulated aberrantly in oncogenically transformed cells. The constitutive expression of genes encoding extracellular proteases, transcription factors, and cytokines is often correlated with cell transformation. In several instances, the uncontrolled expression of these genes is the result of transcriptional activation. Therefore, much attention has been devoted to the study of promoter function in transformed cells. We now review the results of recent investigations on transformation-dependent gene expression. The activation of several transcription factors in oncogenically-transformed cells is described. Results regarding the regulation of promoters through PRD II/kappa B are presented for cells transformed by a variety of oncogenes. Finally, we discuss the significance of transcription factor activation in the process of cell transformation.

Original languageEnglish
Pages (from-to)980-997
Number of pages18
JournalBiochemistry and cell biology = Biochimie et biologie cellulaire
Volume70
Issue number10-11
Publication statusPublished - 1 Oct 1992
Externally publishedYes

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Gene Expression Regulation
Gene expression
Transcription Factors
Chemical activation
Genes
Gene encoding
Gene Expression
Transcriptional Activation
Intercellular Signaling Peptides and Proteins
Peptide Hydrolases
Cytokines
Oncogenes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Regulation of gene expression in oncogenically transformed cells. / Dehbi, Mohammed; Bédard, P. A.

In: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 70, No. 10-11, 01.10.1992, p. 980-997.

Research output: Contribution to journalArticle

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