Regional heterogeneity changes in DCE-MRI as response to isolated limb perfusion in experimental soft-tissue sarcomas

Lejla Alic, M. van Vliet, P. A. Wielopolski, T. L.M. ten Hagen, C. F. van Dijke, W. J. Niessen, J. F. Veenland

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Experimental evidence supports an association between heterogeneity in tumor perfusion and response to chemotherapy/radiotherapy, disease progression and malignancy. Therefore, changes in tumor perfusion may be used to assess early effects of tumor treatment. However, evaluating changes in tumor perfusion during treatment is complicated by extensive changes in tumor type, size, shape and appearance. Therefore, this study assesses the regional heterogeneity of tumors by dynamic contrast-enhanced MRI (DCE-MRI) and evaluates changes in response to isolated limb perfusion (ILP) with tumor necrosis factor alpha and melphalan. Data were acquired in an experimental cancer model, using a macromolecular contrast medium, albumin-(Gd-DTPA)45. Small fragments of BN 175 (a soft-tissue sarcoma) were implanted in eight brown Norway rats. MRI of five drug-treated and three sham-treated rats was performed at baseline and 1 h after ILP intervention. Properly co-registered baseline and follow-up DCE-MRI were used to estimate the volume transfer constant (Ktrans) pharmacokinetic maps. The regional heterogeneity was estimated in 16 tumor sectors and presented in cumulative map-volume histograms. On average, ILP-treated tumors showed a decrease in regional heterogeneity on the histograms. This study shows that heterogenic changes in regional tumor perfusion, estimated using DCE-MRI pharmacokinetic maps, can be measured and used to assess the short-term effects of a potentially curative treatment on the tumor microvasculature in an experimental soft-tissue sarcoma model.

Original languageEnglish
Pages (from-to)340-349
Number of pages10
JournalContrast Media and Molecular Imaging
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Jul 2013
Externally publishedYes

Fingerprint

Sarcoma
Extremities
Perfusion
Neoplasms
Pharmacokinetics
Melphalan
Microvessels
Contrast Media
Disease Progression
Theoretical Models
Radiotherapy
Therapeutics
Tumor Necrosis Factor-alpha
Drug Therapy

Keywords

  • Dynamic contrast-enhanced magnetic resonance imaging
  • Isolated limb perfusion
  • Soft-tissue sarcoma treatment
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Alic, L., van Vliet, M., Wielopolski, P. A., ten Hagen, T. L. M., van Dijke, C. F., Niessen, W. J., & Veenland, J. F. (2013). Regional heterogeneity changes in DCE-MRI as response to isolated limb perfusion in experimental soft-tissue sarcomas. Contrast Media and Molecular Imaging, 8(4), 340-349. https://doi.org/10.1002/cmmi.1528

Regional heterogeneity changes in DCE-MRI as response to isolated limb perfusion in experimental soft-tissue sarcomas. / Alic, Lejla; van Vliet, M.; Wielopolski, P. A.; ten Hagen, T. L.M.; van Dijke, C. F.; Niessen, W. J.; Veenland, J. F.

In: Contrast Media and Molecular Imaging, Vol. 8, No. 4, 01.07.2013, p. 340-349.

Research output: Contribution to journalArticle

Alic, L, van Vliet, M, Wielopolski, PA, ten Hagen, TLM, van Dijke, CF, Niessen, WJ & Veenland, JF 2013, 'Regional heterogeneity changes in DCE-MRI as response to isolated limb perfusion in experimental soft-tissue sarcomas', Contrast Media and Molecular Imaging, vol. 8, no. 4, pp. 340-349. https://doi.org/10.1002/cmmi.1528
Alic, Lejla ; van Vliet, M. ; Wielopolski, P. A. ; ten Hagen, T. L.M. ; van Dijke, C. F. ; Niessen, W. J. ; Veenland, J. F. / Regional heterogeneity changes in DCE-MRI as response to isolated limb perfusion in experimental soft-tissue sarcomas. In: Contrast Media and Molecular Imaging. 2013 ; Vol. 8, No. 4. pp. 340-349.
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