Regional distribution of cystic fibrosis linked DNA haplotypes in Italy, a collaborative study.

P. Gasparini, N. Cappello, B. Dallapiccola, M. Devoto, Xavier P. Estivill, M. Ferrari, G. Leoni, G. Novelli, A. Piazza, P. F. Pignatti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In view of the reported variations of cystic fibrosis (CF) associated haplotypes among populations, a detailed analysis of the distribution of two tightly linked DNA markers (Xv-2c and KM.19) in 18 Italian regions was performed. Haplotypes were determined for 405 CF chromosomes carrying the mutation, and showed significant heterogeneity between the North, Center, and South of Italy and the island of Sardinia. KM.19/PstI Restriction Fragment Length Polymorphism (RFLP) showed significant heterogeneity in these four areas, and was statistically correlated with the geographic distribution of the disease, while Xv-2c/TaqI polymorphism, like the haplotypes of normal chromosomes, was more uniformly distributed over the same four areas. Correlation coefficients between the markers and the mutation have been used to obtain additional indications on the physical distance between the markers and the fibrosis locus.

Original languageEnglish
Pages (from-to)53-64
Number of pages12
JournalGene Geography
Volume4
Issue number1
Publication statusPublished - Apr 1990
Externally publishedYes

Fingerprint

Cystic Fibrosis
Haplotypes
Italy
DNA
Chromosomes
Mutation
Genetic Markers
Islands
Restriction Fragment Length Polymorphisms
Fibrosis
Population

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Gasparini, P., Cappello, N., Dallapiccola, B., Devoto, M., Estivill, X. P., Ferrari, M., ... Pignatti, P. F. (1990). Regional distribution of cystic fibrosis linked DNA haplotypes in Italy, a collaborative study. Gene Geography, 4(1), 53-64.

Regional distribution of cystic fibrosis linked DNA haplotypes in Italy, a collaborative study. / Gasparini, P.; Cappello, N.; Dallapiccola, B.; Devoto, M.; Estivill, Xavier P.; Ferrari, M.; Leoni, G.; Novelli, G.; Piazza, A.; Pignatti, P. F.

In: Gene Geography, Vol. 4, No. 1, 04.1990, p. 53-64.

Research output: Contribution to journalArticle

Gasparini, P, Cappello, N, Dallapiccola, B, Devoto, M, Estivill, XP, Ferrari, M, Leoni, G, Novelli, G, Piazza, A & Pignatti, PF 1990, 'Regional distribution of cystic fibrosis linked DNA haplotypes in Italy, a collaborative study.', Gene Geography, vol. 4, no. 1, pp. 53-64.
Gasparini P, Cappello N, Dallapiccola B, Devoto M, Estivill XP, Ferrari M et al. Regional distribution of cystic fibrosis linked DNA haplotypes in Italy, a collaborative study. Gene Geography. 1990 Apr;4(1):53-64.
Gasparini, P. ; Cappello, N. ; Dallapiccola, B. ; Devoto, M. ; Estivill, Xavier P. ; Ferrari, M. ; Leoni, G. ; Novelli, G. ; Piazza, A. ; Pignatti, P. F. / Regional distribution of cystic fibrosis linked DNA haplotypes in Italy, a collaborative study. In: Gene Geography. 1990 ; Vol. 4, No. 1. pp. 53-64.
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