Reduced regional brain cortical thickness in patients with heart failure

Rajesh Kumar, Santosh K. Yadav, Jose A. Palomares, Bumhee Park, Shantanu H. Joshi, Jennifer A. Ogren, Paul M. Macey, Gregg C. Fonarow, Ronald M. Harper, Mary A. Woo

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Abstract

Aims: Autonomic, cognitive, and neuropsychologic deficits appear in heart failure (HF) subjects, and these compromised functions depend on cerebral cortex integrity in addition to that of subcortical and brainstem sites. Impaired autoregulation, low cardiac output, sleep-disordered-breathing, hypertension, and diabetic conditions in HF offer considerable potential to affect cortical areas by loss of neurons and glia, which would be expressed as reduced cortical thicknesses. However, except for gross descriptions of cortical volume loss/injury, regional cortical thickness integrity in HF is unknown. Our goal was to assess regional cortical thicknesses across the brain in HF, compared to control subjects. Methods and Results: We examined localized cortical thicknesses in 35 HF and 61 control subjects with high-resolution T1-weighted images (3.0-Tesla MRI) using FreeSurfer software, and assessed group differences with analysis-of-covariance (covariates; age, gender; p<0.05; FDR). Significantly-reduced cortical thicknesses appeared in HF over controls in multiple areas, including the frontal, parietal, temporal, and occipital lobes, more markedly on the left side, within areas that control autonomic, cognitive, affective, language, and visual functions. Conclusion: Heart failure subjects show reduced regional cortical thicknesses in sites that control autonomic, cognitive, affective, language, and visual functions that are deficient in the condition. The findings suggest chronic tissue alterations, with regional changes reflecting loss of neurons and glia, and presumably are related to earlier-described axonal changes. The pathological mechanisms contributing to reduced cortical thicknesses likely include hypoxia/ischemia, accompanying impaired cerebral perfusion from reduced cardiac output and sleep-disordered-breathing and other comorbidities in HF.

Original languageEnglish
Article numbere0126595
JournalPloS one
Volume10
Issue number5
DOIs
Publication statusPublished - 11 May 2015

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kumar, R., Yadav, S. K., Palomares, J. A., Park, B., Joshi, S. H., Ogren, J. A., Macey, P. M., Fonarow, G. C., Harper, R. M., & Woo, M. A. (2015). Reduced regional brain cortical thickness in patients with heart failure. PloS one, 10(5), [e0126595]. https://doi.org/10.1371/journal.pone.0126595