Redistribution of T Lymphocytes in the Lymph Nodes of Patients with Sarcoidosis

G. Semenzato, A. Pezzutto, M. Chilosi, G. Pizzolo, Gary W. Hunninghake, Ronald Crystal

Research output: Contribution to journalLetter

50 Citations (Scopus)


To the Editor: Sarcoidosis is a multisystem disease characterized by the presence of noncaseating granulomas in many organs. Since immunologic abnormalities have long been recognized in patients with sarcoidosis, an immune mechanism has been suggested in the pathogenesis of the disease.1,2 Hunninghake and Crystal reported in the August 20 issue that an excess of helper T lymphocytes, as defined by monoclonal antibodies, was present in the lungs of patients with active sarcoidosis.3 On the other hand, consistently lower proportions of helper cells have been demonstrated in the blood of these patients.3 4 5 A possible explanation for the above findings is.

Original languageEnglish
Pages (from-to)48-49
Number of pages2
JournalNew England Journal of Medicine
Issue number1
Publication statusPublished - 7 Jan 1982
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this