Recruitment of members of high-risk Utah pedigrees

Roger R. Williams, Steven Hunt

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Cardiovascular Genetics Research Projects in Utah are designed to investigate genetic and environmental determinants of early coronary disease, stroke, and hypertension in population-based pedigrees. Early coronary disease is defined as the occurence of documented coronary death or myocardial infarction before age 55. Detailed recruitment experience is reported for 2500 persons age 3-83 years in 98 high-risk pedigrees from three ascertainment groups: 1. 1. Descendants of sibships with two or more stroke deaths before age 75. 2. 2. Descendants of sibships with two or more coronary deaths before age 55. 3. 3. First- and second-degree relatives of hypertensive and normotensive probands randomly selected from the Utah Hypertension Detection and Follow-up Program. A response rate of 94% of invited adults attending the first 4-hour clinic visit for detailed screening in 1980-1983 was achieved by multiple telephone, mail, and personal contacts and rescheduling of missed clinic appointments. For the same participants, a second screening cycle in 1983-1986 showed a 91% response of invited adults. Second visit response rates were examined within subgroups according to data collected at the first clinic visit. Below average response rates included 79% of persons with fewer than 12 years of education, 84% of current smokers, and 86% of divorced persons. Above average response rates included 93% of persons attending college and 95% of persons with total family income above $25,000. There were no differences in response according to sex or age. The average cost of recruitment was $59 per person and represented about 10% of the total budget for the High-Risk Pedigree Project.

Original languageEnglish
Pages (from-to)105-114
Number of pages10
JournalControlled Clinical Trials
Volume8
Issue number4 SUPPL. 1
DOIs
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Pedigree
Ambulatory Care
Coronary Disease
Stroke
Hypertension
Genetic Research
Divorce
Postal Service
Budgets
Telephone
Appointments and Schedules
Myocardial Infarction
Education
Costs and Cost Analysis
Population

Keywords

  • coronary disease
  • epidemiology
  • genetics
  • hypertension
  • stroke

ASJC Scopus subject areas

  • Pharmacology

Cite this

Recruitment of members of high-risk Utah pedigrees. / Williams, Roger R.; Hunt, Steven.

In: Controlled Clinical Trials, Vol. 8, No. 4 SUPPL. 1, 1987, p. 105-114.

Research output: Contribution to journalArticle

Williams, Roger R. ; Hunt, Steven. / Recruitment of members of high-risk Utah pedigrees. In: Controlled Clinical Trials. 1987 ; Vol. 8, No. 4 SUPPL. 1. pp. 105-114.
@article{ec87916e18f040e68c5dddba0f2011d9,
title = "Recruitment of members of high-risk Utah pedigrees",
abstract = "Cardiovascular Genetics Research Projects in Utah are designed to investigate genetic and environmental determinants of early coronary disease, stroke, and hypertension in population-based pedigrees. Early coronary disease is defined as the occurence of documented coronary death or myocardial infarction before age 55. Detailed recruitment experience is reported for 2500 persons age 3-83 years in 98 high-risk pedigrees from three ascertainment groups: 1. 1. Descendants of sibships with two or more stroke deaths before age 75. 2. 2. Descendants of sibships with two or more coronary deaths before age 55. 3. 3. First- and second-degree relatives of hypertensive and normotensive probands randomly selected from the Utah Hypertension Detection and Follow-up Program. A response rate of 94{\%} of invited adults attending the first 4-hour clinic visit for detailed screening in 1980-1983 was achieved by multiple telephone, mail, and personal contacts and rescheduling of missed clinic appointments. For the same participants, a second screening cycle in 1983-1986 showed a 91{\%} response of invited adults. Second visit response rates were examined within subgroups according to data collected at the first clinic visit. Below average response rates included 79{\%} of persons with fewer than 12 years of education, 84{\%} of current smokers, and 86{\%} of divorced persons. Above average response rates included 93{\%} of persons attending college and 95{\%} of persons with total family income above $25,000. There were no differences in response according to sex or age. The average cost of recruitment was $59 per person and represented about 10{\%} of the total budget for the High-Risk Pedigree Project.",
keywords = "coronary disease, epidemiology, genetics, hypertension, stroke",
author = "Williams, {Roger R.} and Steven Hunt",
year = "1987",
doi = "10.1016/0197-2456(87)90013-4",
language = "English",
volume = "8",
pages = "105--114",
journal = "Controlled Clinical Trials",
issn = "0197-2456",
publisher = "Elsevier BV",
number = "4 SUPPL. 1",

}

TY - JOUR

T1 - Recruitment of members of high-risk Utah pedigrees

AU - Williams, Roger R.

AU - Hunt, Steven

PY - 1987

Y1 - 1987

N2 - Cardiovascular Genetics Research Projects in Utah are designed to investigate genetic and environmental determinants of early coronary disease, stroke, and hypertension in population-based pedigrees. Early coronary disease is defined as the occurence of documented coronary death or myocardial infarction before age 55. Detailed recruitment experience is reported for 2500 persons age 3-83 years in 98 high-risk pedigrees from three ascertainment groups: 1. 1. Descendants of sibships with two or more stroke deaths before age 75. 2. 2. Descendants of sibships with two or more coronary deaths before age 55. 3. 3. First- and second-degree relatives of hypertensive and normotensive probands randomly selected from the Utah Hypertension Detection and Follow-up Program. A response rate of 94% of invited adults attending the first 4-hour clinic visit for detailed screening in 1980-1983 was achieved by multiple telephone, mail, and personal contacts and rescheduling of missed clinic appointments. For the same participants, a second screening cycle in 1983-1986 showed a 91% response of invited adults. Second visit response rates were examined within subgroups according to data collected at the first clinic visit. Below average response rates included 79% of persons with fewer than 12 years of education, 84% of current smokers, and 86% of divorced persons. Above average response rates included 93% of persons attending college and 95% of persons with total family income above $25,000. There were no differences in response according to sex or age. The average cost of recruitment was $59 per person and represented about 10% of the total budget for the High-Risk Pedigree Project.

AB - Cardiovascular Genetics Research Projects in Utah are designed to investigate genetic and environmental determinants of early coronary disease, stroke, and hypertension in population-based pedigrees. Early coronary disease is defined as the occurence of documented coronary death or myocardial infarction before age 55. Detailed recruitment experience is reported for 2500 persons age 3-83 years in 98 high-risk pedigrees from three ascertainment groups: 1. 1. Descendants of sibships with two or more stroke deaths before age 75. 2. 2. Descendants of sibships with two or more coronary deaths before age 55. 3. 3. First- and second-degree relatives of hypertensive and normotensive probands randomly selected from the Utah Hypertension Detection and Follow-up Program. A response rate of 94% of invited adults attending the first 4-hour clinic visit for detailed screening in 1980-1983 was achieved by multiple telephone, mail, and personal contacts and rescheduling of missed clinic appointments. For the same participants, a second screening cycle in 1983-1986 showed a 91% response of invited adults. Second visit response rates were examined within subgroups according to data collected at the first clinic visit. Below average response rates included 79% of persons with fewer than 12 years of education, 84% of current smokers, and 86% of divorced persons. Above average response rates included 93% of persons attending college and 95% of persons with total family income above $25,000. There were no differences in response according to sex or age. The average cost of recruitment was $59 per person and represented about 10% of the total budget for the High-Risk Pedigree Project.

KW - coronary disease

KW - epidemiology

KW - genetics

KW - hypertension

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=0023475672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023475672&partnerID=8YFLogxK

U2 - 10.1016/0197-2456(87)90013-4

DO - 10.1016/0197-2456(87)90013-4

M3 - Article

VL - 8

SP - 105

EP - 114

JO - Controlled Clinical Trials

JF - Controlled Clinical Trials

SN - 0197-2456

IS - 4 SUPPL. 1

ER -