Recombinant proteins of therapeutic interest expressed by lymphoid cell lines derived from transgenic mice

Andrea Pavirani, Tim Skem, Marianne Le Meur, Yves Lutz, Richard Lathe, Ronald Crystal, Jean Paul Fuchs, Pierre Gerlinger, Michael Courtney

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14 Citations (Scopus)

Abstract

As a new approach to produce human proteins of therapeutic interest we have derived lymphoid cell lines expressing such proteins from transgenic mice, either by generating trans-hybridomas by cell fusion in vitro or by one gene mediated immortalisation in vivo of transgenic lymphocytes. The latter procedure could be applied to different cell types for the expression of proteins that require tissue specific modifications.

Original languageEnglish
Pages (from-to)1049-1054
Number of pages6
JournalNature Biotechnology
Volume7
Issue number10
DOIs
Publication statusPublished - 1 Jan 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

Cite this

Pavirani, A., Skem, T., Meur, M. L., Lutz, Y., Lathe, R., Crystal, R., Fuchs, J. P., Gerlinger, P., & Courtney, M. (1989). Recombinant proteins of therapeutic interest expressed by lymphoid cell lines derived from transgenic mice. Nature Biotechnology, 7(10), 1049-1054. https://doi.org/10.1038/nbt1089-1049