Reactive oxygen species, amp-Activated protein kinase, and the transcription cofactor p300 regulate α-Tubulin acetyltransferase-1 (αtat-1/mec-17)-Dependent microtubule hyperacetylation during cell stress

Rafah Mackeh, Séverine Lorin, Ameetha Ratier, Najet Mejdoubi-Charef, Anita Baillet, Arnaud Bruneel, Ahmed Hamaï, Patrice Codogno, Christian Poüs, Daniel Perdiz

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37 Citations (Scopus)

Abstract

Background: Tubulin acetylation is a hallmark of microtubule stabilization, which may modulate the binding of microtubule-associated proteins. Results: Microtubules are hyperacetylated because of stress-induced cellular signaling upstream of the tubulin acetyltransferase MEC-17/αTAT1. Conclusion: MEC-17/αTAT1 is regulated by p300, reactive oxygen species, and AMP-activated protein kinase. Significance: Microtubule hyperacetylation is important for cell adaptation to stress through autophagy induction and for cell survival.

Original languageEnglish
Pages (from-to)11816-11828
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
Publication statusPublished - 25 Apr 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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