Reactive oxygen species, amp-Activated protein kinase, and the transcription cofactor p300 regulate α-Tubulin acetyltransferase-1 (αtat-1/mec-17)-Dependent microtubule hyperacetylation during cell stress

Rafah Mackeh, Séverine Lorin, Ameetha Ratier, Najet Mejdoubi-Charef, Anita Baillet, Arnaud Bruneel, Ahmed Hamaï, Patrice Codogno, Christian Poüs, Daniel Perdiz

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Tubulin acetylation is a hallmark of microtubule stabilization, which may modulate the binding of microtubule-associated proteins. Results: Microtubules are hyperacetylated because of stress-induced cellular signaling upstream of the tubulin acetyltransferase MEC-17/αTAT1. Conclusion: MEC-17/αTAT1 is regulated by p300, reactive oxygen species, and AMP-activated protein kinase. Significance: Microtubule hyperacetylation is important for cell adaptation to stress through autophagy induction and for cell survival.

Original languageEnglish
Pages (from-to)11816-11828
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
Publication statusPublished - 25 Apr 2014
Externally publishedYes

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Acetyltransferases
Transcription
Tubulin
Microtubules
Protein Kinases
Reactive Oxygen Species
Cell signaling
Acetylation
AMP-Activated Protein Kinases
Microtubule-Associated Proteins
Stabilization
Cells
Autophagy
Cell Survival

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Reactive oxygen species, amp-Activated protein kinase, and the transcription cofactor p300 regulate α-Tubulin acetyltransferase-1 (αtat-1/mec-17)-Dependent microtubule hyperacetylation during cell stress. / Mackeh, Rafah; Lorin, Séverine; Ratier, Ameetha; Mejdoubi-Charef, Najet; Baillet, Anita; Bruneel, Arnaud; Hamaï, Ahmed; Codogno, Patrice; Poüs, Christian; Perdiz, Daniel.

In: Journal of Biological Chemistry, Vol. 289, No. 17, 25.04.2014, p. 11816-11828.

Research output: Contribution to journalArticle

Mackeh, Rafah ; Lorin, Séverine ; Ratier, Ameetha ; Mejdoubi-Charef, Najet ; Baillet, Anita ; Bruneel, Arnaud ; Hamaï, Ahmed ; Codogno, Patrice ; Poüs, Christian ; Perdiz, Daniel. / Reactive oxygen species, amp-Activated protein kinase, and the transcription cofactor p300 regulate α-Tubulin acetyltransferase-1 (αtat-1/mec-17)-Dependent microtubule hyperacetylation during cell stress. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 17. pp. 11816-11828.
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AU - Ratier, Ameetha

AU - Mejdoubi-Charef, Najet

AU - Baillet, Anita

AU - Bruneel, Arnaud

AU - Hamaï, Ahmed

AU - Codogno, Patrice

AU - Poüs, Christian

AU - Perdiz, Daniel

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