Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease

Eva C. Schulte, Akio Fukumori, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J. Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters & 7 others Christian Gieger, Xavier P. Estivill, Thomas Meitinger, Hans A. Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann

Research output: Contribution to journalArticle

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Abstract

Many individuals with Parkinson's disease (PD) develop cognitive deficits, and a phenotypic and molecular overlap between neurodegenerative diseases exists. We investigated the contribution of rare variants in seven genes of known relevance to dementias (β-amyloid precursor protein (APP), PSEN1/2, MAPT (microtubule-associated protein tau), fused in sarcoma (FUS), granulin (GRN) and TAR DNA-binding protein 43 (TDP-43)) to PD and PD plus dementia (PD+D) in a discovery sample of 376 individuals with PD and followed by the genotyping of 25 out of the 27 identified variants with a minor allele frequency <5% in 975 individuals with PD, 93 cases with Lewy body disease on neuropathological examination, 613 individuals with Alzheimer's disease (AD), 182 cases with frontotemporal dementia and 1014 general population controls. Variants identified in APP were functionally followed up by Aβ mass spectrometry in transiently transfected HEK293 cells. PD+D cases harbored more rare variants across all the seven genes than PD individuals without dementia, and rare variants in APP were more common in PD cases overall than in either the AD cases or controls. When additional controls from publically available databases were added, one rare variant in APP (c.1795G>A(p.(E599K))) was significantly associated with the PD phenotype but was not found in either the PD cases or controls of an independent replication sample. One of the identified rare variants (c.2125G>A (p.(G709S))) shifted the Aβ spectrum from Aβ40 to Aβ39 and Aβ37. Although the precise mechanism remains to be elucidated, our data suggest a possible role for APP in modifying the PD phenotype as well as a general contribution of genetic factors to the development of dementia in individuals with PD.

Original languageEnglish
Pages (from-to)1328-1333
Number of pages6
JournalEuropean Journal of Human Genetics
Volume23
Issue number10
DOIs
Publication statusPublished - 22 Oct 2015
Externally publishedYes

Fingerprint

Amyloid beta-Protein Precursor
Parkinson Disease
Dementia
Phenotype
Microtubule-Associated Proteins
DNA-Binding Proteins
Gene Frequency
Sarcoma
Neurodegenerative Diseases

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Schulte, E. C., Fukumori, A., Mollenhauer, B., Hor, H., Arzberger, T., Perneczky, R., ... Winkelmann, J. (2015). Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European Journal of Human Genetics, 23(10), 1328-1333. https://doi.org/10.1038/ejhg.2014.300

Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. / Schulte, Eva C.; Fukumori, Akio; Mollenhauer, Brit; Hor, Hyun; Arzberger, Thomas; Perneczky, Robert; Kurz, Alexander; Diehl-Schmid, Janine; Hüll, Michael; Lichtner, Peter; Eckstein, Gertrud; Zimprich, Alexander; Haubenberger, Dietrich; Pirker, Walter; Brücke, Thomas; Bereznai, Benjamin; Molnar, Maria J.; Lorenzo-Betancor, Oswaldo; Pastor, Pau; Peters, Annette; Gieger, Christian; Estivill, Xavier P.; Meitinger, Thomas; Kretzschmar, Hans A.; Trenkwalder, Claudia; Haass, Christian; Winkelmann, Juliane.

In: European Journal of Human Genetics, Vol. 23, No. 10, 22.10.2015, p. 1328-1333.

Research output: Contribution to journalArticle

Schulte, EC, Fukumori, A, Mollenhauer, B, Hor, H, Arzberger, T, Perneczky, R, Kurz, A, Diehl-Schmid, J, Hüll, M, Lichtner, P, Eckstein, G, Zimprich, A, Haubenberger, D, Pirker, W, Brücke, T, Bereznai, B, Molnar, MJ, Lorenzo-Betancor, O, Pastor, P, Peters, A, Gieger, C, Estivill, XP, Meitinger, T, Kretzschmar, HA, Trenkwalder, C, Haass, C & Winkelmann, J 2015, 'Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease', European Journal of Human Genetics, vol. 23, no. 10, pp. 1328-1333. https://doi.org/10.1038/ejhg.2014.300
Schulte EC, Fukumori A, Mollenhauer B, Hor H, Arzberger T, Perneczky R et al. Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European Journal of Human Genetics. 2015 Oct 22;23(10):1328-1333. https://doi.org/10.1038/ejhg.2014.300
Schulte, Eva C. ; Fukumori, Akio ; Mollenhauer, Brit ; Hor, Hyun ; Arzberger, Thomas ; Perneczky, Robert ; Kurz, Alexander ; Diehl-Schmid, Janine ; Hüll, Michael ; Lichtner, Peter ; Eckstein, Gertrud ; Zimprich, Alexander ; Haubenberger, Dietrich ; Pirker, Walter ; Brücke, Thomas ; Bereznai, Benjamin ; Molnar, Maria J. ; Lorenzo-Betancor, Oswaldo ; Pastor, Pau ; Peters, Annette ; Gieger, Christian ; Estivill, Xavier P. ; Meitinger, Thomas ; Kretzschmar, Hans A. ; Trenkwalder, Claudia ; Haass, Christian ; Winkelmann, Juliane. / Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. In: European Journal of Human Genetics. 2015 ; Vol. 23, No. 10. pp. 1328-1333.
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