Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom

Maheshi N. Ramasamy, Elizabeth A. Clutterbuck, Kathryn Haworth, Jaclyn Bowman, Omar Omar, Amber J. Thompson, Geraldine Blanchard-Rohner, Ly Mee Yu, Matthew D. Snape, Andrew J. Pollard

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).

Original languageEnglish
Pages (from-to)1164-1168
Number of pages5
JournalClinical and Vaccine Immunology
Volume21
Issue number8
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

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Meningococcal Vaccines
Conjugate Vaccines
Polysaccharides
Vaccines
Randomized Controlled Trials
Meningitis
Antibody Formation
Sepsis
Antibodies
United Kingdom

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

Cite this

Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom. / Ramasamy, Maheshi N.; Clutterbuck, Elizabeth A.; Haworth, Kathryn; Bowman, Jaclyn; Omar, Omar; Thompson, Amber J.; Blanchard-Rohner, Geraldine; Yu, Ly Mee; Snape, Matthew D.; Pollard, Andrew J.

In: Clinical and Vaccine Immunology, Vol. 21, No. 8, 01.01.2014, p. 1164-1168.

Research output: Contribution to journalArticle

Ramasamy, MN, Clutterbuck, EA, Haworth, K, Bowman, J, Omar, O, Thompson, AJ, Blanchard-Rohner, G, Yu, LM, Snape, MD & Pollard, AJ 2014, 'Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom', Clinical and Vaccine Immunology, vol. 21, no. 8, pp. 1164-1168. https://doi.org/10.1128/CVI.00099-14
Ramasamy, Maheshi N. ; Clutterbuck, Elizabeth A. ; Haworth, Kathryn ; Bowman, Jaclyn ; Omar, Omar ; Thompson, Amber J. ; Blanchard-Rohner, Geraldine ; Yu, Ly Mee ; Snape, Matthew D. ; Pollard, Andrew J. / Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom. In: Clinical and Vaccine Immunology. 2014 ; Vol. 21, No. 8. pp. 1164-1168.
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