Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom

Maheshi N. Ramasamy; Elizabeth A. Clutterbuck; Kathryn Haworth; Jaclyn Bowman; Omar Omar; Amber J. Thompson; Geraldine Blanchard-Rohner; Ly Mee Yu; Matthew D. Snape; Andrew J. Pollard

doi:10.1128/CVI.00099-14

Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom

Maheshi N. Ramasamy, Elizabeth A. Clutterbuck, Kathryn Haworth, Jaclyn Bowman, Omar Omar, Amber J. Thompson, Geraldine Blanchard-Rohner, Ly Mee Yu, Matthew D. Snape, Andrew J. Pollard

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).

Original language	English
Pages (from-to)	1164-1168
Number of pages	5
Journal	Clinical and Vaccine Immunology
Volume	21
Issue number	8
DOIs	https://doi.org/10.1128/CVI.00099-14
Publication status	Published - 1 Jan 2014
Externally published	Yes

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ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

Cite this

Ramasamy, M. N., Clutterbuck, E. A., Haworth, K., Bowman, J., Omar, O., Thompson, A. J., Blanchard-Rohner, G., Yu, L. M., Snape, M. D., & Pollard, A. J. (2014). Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom. Clinical and Vaccine Immunology, 21(8), 1164-1168. https://doi.org/10.1128/CVI.00099-14

Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom. / Ramasamy, Maheshi N.; Clutterbuck, Elizabeth A.; Haworth, Kathryn; Bowman, Jaclyn; Omar, Omar; Thompson, Amber J.; Blanchard-Rohner, Geraldine; Yu, Ly Mee; Snape, Matthew D.; Pollard, Andrew J.

In: Clinical and Vaccine Immunology, Vol. 21, No. 8, 01.01.2014, p. 1164-1168.

Research output: Contribution to journal › Article

Ramasamy, MN, Clutterbuck, EA, Haworth, K, Bowman, J, Omar, O, Thompson, AJ, Blanchard-Rohner, G, Yu, LM, Snape, MD & Pollard, AJ 2014, 'Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom', Clinical and Vaccine Immunology, vol. 21, no. 8, pp. 1164-1168. https://doi.org/10.1128/CVI.00099-14

Ramasamy, Maheshi N. ; Clutterbuck, Elizabeth A. ; Haworth, Kathryn ; Bowman, Jaclyn ; Omar, Omar ; Thompson, Amber J. ; Blanchard-Rohner, Geraldine ; Yu, Ly Mee ; Snape, Matthew D. ; Pollard, Andrew J. / Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United Kingdom. In: Clinical and Vaccine Immunology. 2014 ; Vol. 21, No. 8. pp. 1164-1168.

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10.1128/CVI.00099-14