Purpose: To estimate precontrast tissue parameter (T10) using fast spin echo (FSE) and to quantify physiological and hemodynamic parameters with leakage correction using T1-weighted dynamic contrast-enhanced (DCE) perfusion imaging. Materials and Methods: Voxel-wise T10 computation was performed followed by the analysis of T1-weighted DCE perfusion data for the conversion of signal intensity time curve to concentration time curve, estimation of hemodynamic and physiological perfusion indices, and a method for leakage correction. Validations of accuracy of the computations have also been carried out. Results: The computed T10 and hemodynamic perfusion indices in normal white and gray matter were in good agreement with the literature values. Physiological perfusion indices in these regions were found negligible, validating computations. Cerebral blood volume (CBV) values change negligibly over the length of concentration time curve in white matter, gray matter, and lesion (CBVcorrected), while CBV uncorrected (lesion) shows linear increase over time. Conclusion: T1-weighted DCE perfusion data along with FSE-based T1 estimation can be used for an accurate estimation of hemodynamic and physiological perfusion indices.
- Concentration time curve
- Leakage volume
- Perfusion indices
- Signal intensity time curve
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology