QTLs of factors of the metabolic syndrome and echocardiographic phenotypes

The hypertension genetic epidemiology network study

Aldi T. Kraja, Pinchia Huang, Weihong Tang, Steven Hunt, Kari E. North, Cora E. Lewis, Richard B. Devereux, Giovanni de Simone, Donna K. Arnett, Treva Rice, D. C. Rao

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: In a previous study of the Hypertension Genetic Epidemiology Network (HyperGEN) we have shown that metabolic syndrome (MetS) risk factors were moderately and significantly associated with echocardiographic (ECHO) left ventricular (LV) phenotypes. Methods: The study included 1,393 African Americans and 1,133 whites, stratified by type 2 diabetes mellitus (DM) status. Heritabilities of seven factor scores based on the analysis of 15 traits were sufficiently high to pursue QTL discovery in this follow-up study. Results: Three of the QTLs discovered relate to combined MetS-ECHO factors of "blood pressure (BP)-LV wall thickness" on chromosome 3 at 225 cM with a 2.8 LOD score, on chromosome 20 at 2.1 cM with a 2.6 LOD score; and for "LV wall thickness" factor on chromosome 16 at 113.5 with a 2.6 LOD score in whites. The remaining QTLs include one for a "body mass index-insulin (BMI-INS)" factor with a LOD score of 3.9 on chromosome 2 located at 64.8 cM; one for the same factor on chromosome 12 at 91.4 cM with a 3.3 LOD score; one for a "BP" factor on chromosome 19 located at 67.8 cM with a 3.0 LOD score. A suggestive linkage was also found for "Lipids-INS" with a 2.7 LOD score located on chromosome 11 at 113.1 cM in African Americans. Of the above QTLs, the one on chromosome 12 for "BMI-INS" is replicated in both ethnicities, (with highest LOD scores in African Americans). In addition, the QTL for "LV wall thickness" on chromosome 16q24.2-q24.3 reached its local maximum LOD score at marker D16S402, which is positioned within the 5th intron of the cadherin 13 gene, implicated in heart and vascular remodeling. Conclusion: Our previous study and this follow-up suggest gene loci for some crucial MetS and cardiac geometry risk factors that contribute to the risk of developing heart disease.

Original languageEnglish
Article number103
JournalBMC Medical Genetics
Volume9
DOIs
Publication statusPublished - 27 Nov 2008
Externally publishedYes

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Molecular Epidemiology
African Americans
Chromosomes, Human, Pair 12
Hypertension
Phenotype
Body Mass Index
Insulin
Chromosomes, Human, Pair 20
Blood Pressure
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 2
Introns
Type 2 Diabetes Mellitus
Genes
Heart Diseases
Chromosomes
Lipids

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

QTLs of factors of the metabolic syndrome and echocardiographic phenotypes : The hypertension genetic epidemiology network study. / Kraja, Aldi T.; Huang, Pinchia; Tang, Weihong; Hunt, Steven; North, Kari E.; Lewis, Cora E.; Devereux, Richard B.; de Simone, Giovanni; Arnett, Donna K.; Rice, Treva; Rao, D. C.

In: BMC Medical Genetics, Vol. 9, 103, 27.11.2008.

Research output: Contribution to journalArticle

Kraja, AT, Huang, P, Tang, W, Hunt, S, North, KE, Lewis, CE, Devereux, RB, de Simone, G, Arnett, DK, Rice, T & Rao, DC 2008, 'QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: The hypertension genetic epidemiology network study', BMC Medical Genetics, vol. 9, 103. https://doi.org/10.1186/1471-2350-9-103
Kraja, Aldi T. ; Huang, Pinchia ; Tang, Weihong ; Hunt, Steven ; North, Kari E. ; Lewis, Cora E. ; Devereux, Richard B. ; de Simone, Giovanni ; Arnett, Donna K. ; Rice, Treva ; Rao, D. C. / QTLs of factors of the metabolic syndrome and echocardiographic phenotypes : The hypertension genetic epidemiology network study. In: BMC Medical Genetics. 2008 ; Vol. 9.
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abstract = "Background: In a previous study of the Hypertension Genetic Epidemiology Network (HyperGEN) we have shown that metabolic syndrome (MetS) risk factors were moderately and significantly associated with echocardiographic (ECHO) left ventricular (LV) phenotypes. Methods: The study included 1,393 African Americans and 1,133 whites, stratified by type 2 diabetes mellitus (DM) status. Heritabilities of seven factor scores based on the analysis of 15 traits were sufficiently high to pursue QTL discovery in this follow-up study. Results: Three of the QTLs discovered relate to combined MetS-ECHO factors of {"}blood pressure (BP)-LV wall thickness{"} on chromosome 3 at 225 cM with a 2.8 LOD score, on chromosome 20 at 2.1 cM with a 2.6 LOD score; and for {"}LV wall thickness{"} factor on chromosome 16 at 113.5 with a 2.6 LOD score in whites. The remaining QTLs include one for a {"}body mass index-insulin (BMI-INS){"} factor with a LOD score of 3.9 on chromosome 2 located at 64.8 cM; one for the same factor on chromosome 12 at 91.4 cM with a 3.3 LOD score; one for a {"}BP{"} factor on chromosome 19 located at 67.8 cM with a 3.0 LOD score. A suggestive linkage was also found for {"}Lipids-INS{"} with a 2.7 LOD score located on chromosome 11 at 113.1 cM in African Americans. Of the above QTLs, the one on chromosome 12 for {"}BMI-INS{"} is replicated in both ethnicities, (with highest LOD scores in African Americans). In addition, the QTL for {"}LV wall thickness{"} on chromosome 16q24.2-q24.3 reached its local maximum LOD score at marker D16S402, which is positioned within the 5th intron of the cadherin 13 gene, implicated in heart and vascular remodeling. Conclusion: Our previous study and this follow-up suggest gene loci for some crucial MetS and cardiac geometry risk factors that contribute to the risk of developing heart disease.",
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T1 - QTLs of factors of the metabolic syndrome and echocardiographic phenotypes

T2 - The hypertension genetic epidemiology network study

AU - Kraja, Aldi T.

AU - Huang, Pinchia

AU - Tang, Weihong

AU - Hunt, Steven

AU - North, Kari E.

AU - Lewis, Cora E.

AU - Devereux, Richard B.

AU - de Simone, Giovanni

AU - Arnett, Donna K.

AU - Rice, Treva

AU - Rao, D. C.

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N2 - Background: In a previous study of the Hypertension Genetic Epidemiology Network (HyperGEN) we have shown that metabolic syndrome (MetS) risk factors were moderately and significantly associated with echocardiographic (ECHO) left ventricular (LV) phenotypes. Methods: The study included 1,393 African Americans and 1,133 whites, stratified by type 2 diabetes mellitus (DM) status. Heritabilities of seven factor scores based on the analysis of 15 traits were sufficiently high to pursue QTL discovery in this follow-up study. Results: Three of the QTLs discovered relate to combined MetS-ECHO factors of "blood pressure (BP)-LV wall thickness" on chromosome 3 at 225 cM with a 2.8 LOD score, on chromosome 20 at 2.1 cM with a 2.6 LOD score; and for "LV wall thickness" factor on chromosome 16 at 113.5 with a 2.6 LOD score in whites. The remaining QTLs include one for a "body mass index-insulin (BMI-INS)" factor with a LOD score of 3.9 on chromosome 2 located at 64.8 cM; one for the same factor on chromosome 12 at 91.4 cM with a 3.3 LOD score; one for a "BP" factor on chromosome 19 located at 67.8 cM with a 3.0 LOD score. A suggestive linkage was also found for "Lipids-INS" with a 2.7 LOD score located on chromosome 11 at 113.1 cM in African Americans. Of the above QTLs, the one on chromosome 12 for "BMI-INS" is replicated in both ethnicities, (with highest LOD scores in African Americans). In addition, the QTL for "LV wall thickness" on chromosome 16q24.2-q24.3 reached its local maximum LOD score at marker D16S402, which is positioned within the 5th intron of the cadherin 13 gene, implicated in heart and vascular remodeling. Conclusion: Our previous study and this follow-up suggest gene loci for some crucial MetS and cardiac geometry risk factors that contribute to the risk of developing heart disease.

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