QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population

Nathalie Marissal-Arvy, Abdoulaye Diane, Marie Pierre Moisan, Christiane Larue-Achagiotis, Claudine Tridon, Daniel Tome, Gilles Fromentin, Pierre Mormède

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective Individual differences in macronutrient selection, particularly fat and carbohydrate, and associated body weight gain are partly inherited as polygenic traits, but the potential genetic pathways are unknown. To give an overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways influencing these differences in rat was aimed in this study. Design and Methods To that end, F2 rats obtained from the crossbreeding between LOU/C and Fischer 344 rat strains to diet self-selection during 3 weeks were submitted. A genome scan was conducted with microsatellite markers covering evenly the whole genome. Genotypes and phenotypes were analyzed separately in male and female F2 rats by multiple interval mapping. Then, lists of candidate genes were treated by the Ingenuity® Pathway software to propose gene pathways involved in our phenotypes. Results Among numerous others, a QTL on chromosome 12 that influences body weight gain, and fat and carbohydrate choices in the LOU/C x Fischer 344 F2 rat population was found. This locus contains notably the acyl-co-A dehydrogenase gene. Conclusion A strong genetic determinism and complex pathways involving numerous candidate genes and processes, notably in accordance with the metabolic theory of feeding behavior control were found.

Original languageEnglish
Pages (from-to)565-575
Number of pages11
JournalObesity
Volume22
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014
Externally publishedYes

Fingerprint

Quantitative Trait Loci
Fats
Carbohydrates
Population
Genes
Weight Gain
Genetic Determinism
Body Weight
Genome
Multifactorial Inheritance
Genetic Hybridization
Phenotype
Chromosomes, Human, Pair 12
Behavior Control
Inbred F344 Rats
Feeding Behavior
Individuality
Microsatellite Repeats
Adipose Tissue
Oxidoreductases

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Marissal-Arvy, N., Diane, A., Moisan, M. P., Larue-Achagiotis, C., Tridon, C., Tome, D., ... Mormède, P. (2014). QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population. Obesity, 22(2), 565-575. https://doi.org/10.1002/oby.20485

QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population. / Marissal-Arvy, Nathalie; Diane, Abdoulaye; Moisan, Marie Pierre; Larue-Achagiotis, Christiane; Tridon, Claudine; Tome, Daniel; Fromentin, Gilles; Mormède, Pierre.

In: Obesity, Vol. 22, No. 2, 01.02.2014, p. 565-575.

Research output: Contribution to journalArticle

Marissal-Arvy, N, Diane, A, Moisan, MP, Larue-Achagiotis, C, Tridon, C, Tome, D, Fromentin, G & Mormède, P 2014, 'QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population', Obesity, vol. 22, no. 2, pp. 565-575. https://doi.org/10.1002/oby.20485
Marissal-Arvy N, Diane A, Moisan MP, Larue-Achagiotis C, Tridon C, Tome D et al. QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population. Obesity. 2014 Feb 1;22(2):565-575. https://doi.org/10.1002/oby.20485
Marissal-Arvy, Nathalie ; Diane, Abdoulaye ; Moisan, Marie Pierre ; Larue-Achagiotis, Christiane ; Tridon, Claudine ; Tome, Daniel ; Fromentin, Gilles ; Mormède, Pierre. / QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population. In: Obesity. 2014 ; Vol. 22, No. 2. pp. 565-575.
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