PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma

Hela Ben Nasr, Karim Chahed, Noureddine Bouaouina, Lotfi Chouchane

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cyclooxygenase-2 (Cox-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins that has been shown to have a particular importance in the progression of several malignancies including nasopharyngeal carcinoma (NPC). In the current report, we designed a case-controlled study to evaluate the susceptibility and prognostic implications of the functional -765 G > C genetic variation in NPC. A PCR and restriction fragment length polymorphism analysis was used to determine the polymorphism in a Tunisian population of patients with NPC (n = 180) and in healthy control subjects (n = 169). A higher risk for NPC was observed for carriers of COX-2 -765 C allele (OR = 1.76; P = 0.01). This association remains significant after adjustments for age and sex (OR = 1.89; P = 0.008). Regarding prognostic indicators, a significant association was found between -765 C allele carriers and the presence of lymph node metastasis (OR = 2.28; P = 0.01), as well as, with tumor stage (OR = 2.73; P = 0.03). This is the first report on the studies of COX-2 SNPs in NPC and our data suggest that this genetic variant may play a role in mediating susceptibility to NPC, as well as, in neoplastic progression, a finding which further supports the involvement of COX-2 in NPC etiology.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalMolecular Biology Reports
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Cyclooxygenase 2
Lymph Nodes
Neoplasm Metastasis
Alleles
Nasopharyngeal carcinoma
Arachidonic Acid
Restriction Fragment Length Polymorphisms
Prostaglandins
Single Nucleotide Polymorphism
Neoplasms
Healthy Volunteers
Polymerase Chain Reaction
Enzymes
Population

Keywords

  • COX-2
  • Nasopharyngeal carcinoma
  • Polymorphism
  • Prognosis
  • Susceptibility

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. / Ben Nasr, Hela; Chahed, Karim; Bouaouina, Noureddine; Chouchane, Lotfi.

In: Molecular Biology Reports, Vol. 36, No. 1, 01.2009, p. 193-200.

Research output: Contribution to journalArticle

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