Protective effects of curcumin against ischemia-reperfusion injury in the liver

Kowsar Bavarsad, Maryam Matbou Riahi, Saeideh Saadat, George Barreto, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement.

Original languageEnglish
Pages (from-to)53-62
Number of pages10
JournalPharmacological Research
Volume141
DOIs
Publication statusPublished - 1 Mar 2019

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Keywords

  • Curcumin
  • Ischemia-reperfusion injury
  • Liver
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology

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