Prostate-specific antigen levels among cirrhotic patients

Meral Akdogan, B. S. Hassoun, A. Gurakar, K. El-Sahwi, A. Jazzar, H. Wright, A. Sebastian, Bakr Nour

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine serum prostate-specific antigen (PSA) levels in patients with liver cirrhosis. Patients and methods: Between January 1995 and August 2001, 216 men with cirrhosis were evaluated. The extent of their liver disease was classified according to the Child-Pugh classification. Serum PSA levels were measured with the Hybritech Tandem-R RIA method and matched with age-related reference PSA levels. Digital rectal examination (DRE) was performed in all patients. Patients with elevated PSA levels and/or abnormal DRE were recommended to undergo further assessment including transrectal ultrasonography (TRUS) and biopsy performed by an urologist. Results: Two hundred and sixteen men (mean age 54.09±9.09 years, range 25-76) with cirrhosis were examined. Their mean PSA value was 0.57±0.84 ng/mL and tended to be lower than in the normal population. The degree of PSA decrease was found to parallel the severity of the liver disease (p=0.002). The mean serum PSA level increased with each age decade in a statistically significant manner (p<0.001). Four patients (three with elevated PSA values) underwent prostate biopsy. Three biopsies were positive for prostate cancer, the other showed evidence of benign prostatic hyperplasia (BPH). Conclusion: Serum PSA is influenced by the severity of liver disease and its levels tend to be lower in cirrhotic patients than in the normal population. However, serum PSA can still be considered a reliable marker in the clinical management of prostatic disease in patients with cirrhosis.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalInternational Journal of Biological Markers
Volume17
Issue number3
Publication statusPublished - Jul 2002
Externally publishedYes

Fingerprint

Prostate-Specific Antigen
Liver
Biopsy
Liver Diseases
Digital Rectal Examination
Serum
Fibrosis
Prostatic Diseases
Ultrasonography
Prostatic Hyperplasia
Liver Cirrhosis
Population
Prostate
Prostatic Neoplasms
Biomarkers

Keywords

  • Liver cirrhosis
  • Prostate-specific antigen

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

Cite this

Akdogan, M., Hassoun, B. S., Gurakar, A., El-Sahwi, K., Jazzar, A., Wright, H., ... Nour, B. (2002). Prostate-specific antigen levels among cirrhotic patients. International Journal of Biological Markers, 17(3), 161-164.

Prostate-specific antigen levels among cirrhotic patients. / Akdogan, Meral; Hassoun, B. S.; Gurakar, A.; El-Sahwi, K.; Jazzar, A.; Wright, H.; Sebastian, A.; Nour, Bakr.

In: International Journal of Biological Markers, Vol. 17, No. 3, 07.2002, p. 161-164.

Research output: Contribution to journalArticle

Akdogan, M, Hassoun, BS, Gurakar, A, El-Sahwi, K, Jazzar, A, Wright, H, Sebastian, A & Nour, B 2002, 'Prostate-specific antigen levels among cirrhotic patients', International Journal of Biological Markers, vol. 17, no. 3, pp. 161-164.
Akdogan M, Hassoun BS, Gurakar A, El-Sahwi K, Jazzar A, Wright H et al. Prostate-specific antigen levels among cirrhotic patients. International Journal of Biological Markers. 2002 Jul;17(3):161-164.
Akdogan, Meral ; Hassoun, B. S. ; Gurakar, A. ; El-Sahwi, K. ; Jazzar, A. ; Wright, H. ; Sebastian, A. ; Nour, Bakr. / Prostate-specific antigen levels among cirrhotic patients. In: International Journal of Biological Markers. 2002 ; Vol. 17, No. 3. pp. 161-164.
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