Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis

Finlay W. Mcnab, Matthew P R Berry, Christine M. Graham, Susannah A A Bloch, Tolu Oni, Katalin A. Wilkinson, Robert J. Wilkinson, Onn M. Kon, Jacques Banchereau, Damien J. Chaussabel, Anne O'Garra

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63 Citations (Scopus)

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's largest infectious disease problems. Despite decades of intensive study, the immune response to Mtb is incompletely characterised, reflecting the extremely complex interaction between pathogen and host. Pathways that may alter the balance between host protection and pathogenesis are therefore of great interest. One pathway shown to play a role in the pathogenesis of chronic infections, including TB, is the programmed death-1 (PD-1) pathway. We show here that the expression of the programmed death ligand 1 (PD-L1), which interacts with PD-1, is increased in whole blood from active TB patients compared with whole blood from healthy controls or Mtb-exposed individuals, and that expression by neutrophils is largely responsible for this increase.

Original languageEnglish
Pages (from-to)1941-1947
Number of pages7
JournalEuropean Journal of Immunology
Volume41
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

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Keywords

  • Neutrophils
  • Programmed death ligand 1
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Mcnab, F. W., Berry, M. P. R., Graham, C. M., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Wilkinson, R. J., Kon, O. M., Banchereau, J., Chaussabel, D. J., & O'Garra, A. (2011). Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. European Journal of Immunology, 41(7), 1941-1947. https://doi.org/10.1002/eji.201141421