Productive Cytomegalovirus Infection Is Associated With Impaired Endothelial Function in ST-Elevation Myocardial Infarction

Anna Lebedeva, Elena Maryukhnich, Jean-Charles B. Grivel, Elena Vasilieva, Leonid Margolis, Alexander Shpektor

Research output: Contribution to journalArticle

Abstract

Background: An association between productive cytomegalovirus infection and atherosclerosis was shown recently in several trials, including a previous study of ours. However, the mechanism involved in this association is still under investigation. Here, we addressed the interaction between productive cytomegalovirus infection and endothelial function in patients with ST-elevation myocardial infarction (STEMI). Methods: We analyzed the presence of cytomegaloviral DNA in plasma and endothelial function in 33 patients with STEMI and 33 volunteers without cardiovascular diseases, using real-time polymerase chain reaction (PCR) and a noninvasive test of flow-mediated dilation. Results: Both the frequency of presence and the load of cytomegaloviral DNA were higher in plasma of patients with STEMI than those in controls. This difference was independent of other cardiovascular risk factors (7.38 [1.36-40.07]; P = 0.02). The results of the flow-mediated dilation test were lower in patients in STEMI than in controls (5.0% [2.65%-3.09%] vs 12. %5 [7.5%-15.15%]; P = 0.004) and correlated negatively with the cytomegaloviral DNA load (Spearman R = −0.407; P = 0.019) independently of other cardiovascular risk factors. Conclusions: Productive cytomegalovirus infection in patients with STEMI correlated negatively with endothelial function independently of other cardiovascular risk factors. The impact of cytomegalovirus on endothelial function may explain the role of cytomegalovirus in cardiovascular prognosis.

Original languageEnglish
JournalAmerican Journal of Medicine
DOIs
Publication statusPublished - 1 Jan 2019

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Keywords

  • Cytomegalovirus
  • Endothelial function
  • Flow-mediated vasodilation
  • Polymerase chain reaction
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)

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