Prevalence of thyroid autoantibodies in children, adolescents and young adults with type 1 diabetes in Kuwait

M. Al-Khawari, A. Shaltout, M. Qabazard, H. Al-Sane, Naser Elkum

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To investigate the prevalence of thyroid autoimmunity among children and adolescents with type 1 diabetes in Kuwait. Subjects and Methods: In a mixed cross-sectional and longitudinal study, anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) were measured in 232 subjects (118 males and 114 females) with type 1 diabetes. Results: The mean age of the total study population was 10.9 ± 3.6 years (range 1-21), and the median diabetes duration was 3.9 years (range 0-16). At the initial screening, 57 out of 232 (24.6%) patients had positive antibodies, and of the remaining 175 patients, who were antibody negative,131 (74.3%) were followed up for 4-9 years. 23 out of these 131 (17.7%) patients became antibody positive, with a cumulative prevalence of elevated antibodies of 34.5%. Anti-TPO was present in 34 (14.7%), anti-TG in 23 (9.9%) and both antibodies in 23 (9.9%) patients. Thyroid antibodies presented early within the first 5 years of the onset of diabetes (63.2 vs. 36.8%, p < 0.05). The prevalence of elevated thyroid antibodies increased after the onset of puberty in both females and males (p < 0.0001). A total of 58.7% of the patients with positive antibodies were females compared to 41% males (p < 0.0001). The basal thyroid-stimulating hormone was higher in subjects with positive antibodies (5.1 ± 10.7 mIU/l) compared to those who were antibody negative (1.79 ± 0.87 mIU/l, p < 0.001). Furthermore, 30 out of 232 (12.9%) patients developed thyroid dysfunction. Conclusion: In this study, a high prevalence of thyroid autoimmune antibodies was found in patients either at the onset of type 1 diabetes or within the 4-9 years of follow-up.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalMedical Principles and Practice
Volume24
Issue number3
DOIs
Publication statusPublished - 28 May 2015
Externally publishedYes

Fingerprint

Kuwait
Type 1 Diabetes Mellitus
Autoantibodies
Young Adult
Thyroid Gland
Antibodies
Iodide Peroxidase
Thyrotropin
Puberty
Autoimmunity
Longitudinal Studies
Cross-Sectional Studies

Keywords

  • Anti-thyroglobulin
  • Anti-thyroid peroxidase
  • Thyroid autoimmune prevalence
  • Thyroid dysfunction
  • Type 1 diabetes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence of thyroid autoantibodies in children, adolescents and young adults with type 1 diabetes in Kuwait. / Al-Khawari, M.; Shaltout, A.; Qabazard, M.; Al-Sane, H.; Elkum, Naser.

In: Medical Principles and Practice, Vol. 24, No. 3, 28.05.2015, p. 280-284.

Research output: Contribution to journalArticle

Al-Khawari, M. ; Shaltout, A. ; Qabazard, M. ; Al-Sane, H. ; Elkum, Naser. / Prevalence of thyroid autoantibodies in children, adolescents and young adults with type 1 diabetes in Kuwait. In: Medical Principles and Practice. 2015 ; Vol. 24, No. 3. pp. 280-284.
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abstract = "To investigate the prevalence of thyroid autoimmunity among children and adolescents with type 1 diabetes in Kuwait. Subjects and Methods: In a mixed cross-sectional and longitudinal study, anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) were measured in 232 subjects (118 males and 114 females) with type 1 diabetes. Results: The mean age of the total study population was 10.9 ± 3.6 years (range 1-21), and the median diabetes duration was 3.9 years (range 0-16). At the initial screening, 57 out of 232 (24.6{\%}) patients had positive antibodies, and of the remaining 175 patients, who were antibody negative,131 (74.3{\%}) were followed up for 4-9 years. 23 out of these 131 (17.7{\%}) patients became antibody positive, with a cumulative prevalence of elevated antibodies of 34.5{\%}. Anti-TPO was present in 34 (14.7{\%}), anti-TG in 23 (9.9{\%}) and both antibodies in 23 (9.9{\%}) patients. Thyroid antibodies presented early within the first 5 years of the onset of diabetes (63.2 vs. 36.8{\%}, p < 0.05). The prevalence of elevated thyroid antibodies increased after the onset of puberty in both females and males (p < 0.0001). A total of 58.7{\%} of the patients with positive antibodies were females compared to 41{\%} males (p < 0.0001). The basal thyroid-stimulating hormone was higher in subjects with positive antibodies (5.1 ± 10.7 mIU/l) compared to those who were antibody negative (1.79 ± 0.87 mIU/l, p < 0.001). Furthermore, 30 out of 232 (12.9{\%}) patients developed thyroid dysfunction. Conclusion: In this study, a high prevalence of thyroid autoimmune antibodies was found in patients either at the onset of type 1 diabetes or within the 4-9 years of follow-up.",
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AU - Al-Khawari, M.

AU - Shaltout, A.

AU - Qabazard, M.

AU - Al-Sane, H.

AU - Elkum, Naser

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N2 - To investigate the prevalence of thyroid autoimmunity among children and adolescents with type 1 diabetes in Kuwait. Subjects and Methods: In a mixed cross-sectional and longitudinal study, anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) were measured in 232 subjects (118 males and 114 females) with type 1 diabetes. Results: The mean age of the total study population was 10.9 ± 3.6 years (range 1-21), and the median diabetes duration was 3.9 years (range 0-16). At the initial screening, 57 out of 232 (24.6%) patients had positive antibodies, and of the remaining 175 patients, who were antibody negative,131 (74.3%) were followed up for 4-9 years. 23 out of these 131 (17.7%) patients became antibody positive, with a cumulative prevalence of elevated antibodies of 34.5%. Anti-TPO was present in 34 (14.7%), anti-TG in 23 (9.9%) and both antibodies in 23 (9.9%) patients. Thyroid antibodies presented early within the first 5 years of the onset of diabetes (63.2 vs. 36.8%, p < 0.05). The prevalence of elevated thyroid antibodies increased after the onset of puberty in both females and males (p < 0.0001). A total of 58.7% of the patients with positive antibodies were females compared to 41% males (p < 0.0001). The basal thyroid-stimulating hormone was higher in subjects with positive antibodies (5.1 ± 10.7 mIU/l) compared to those who were antibody negative (1.79 ± 0.87 mIU/l, p < 0.001). Furthermore, 30 out of 232 (12.9%) patients developed thyroid dysfunction. Conclusion: In this study, a high prevalence of thyroid autoimmune antibodies was found in patients either at the onset of type 1 diabetes or within the 4-9 years of follow-up.

AB - To investigate the prevalence of thyroid autoimmunity among children and adolescents with type 1 diabetes in Kuwait. Subjects and Methods: In a mixed cross-sectional and longitudinal study, anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) were measured in 232 subjects (118 males and 114 females) with type 1 diabetes. Results: The mean age of the total study population was 10.9 ± 3.6 years (range 1-21), and the median diabetes duration was 3.9 years (range 0-16). At the initial screening, 57 out of 232 (24.6%) patients had positive antibodies, and of the remaining 175 patients, who were antibody negative,131 (74.3%) were followed up for 4-9 years. 23 out of these 131 (17.7%) patients became antibody positive, with a cumulative prevalence of elevated antibodies of 34.5%. Anti-TPO was present in 34 (14.7%), anti-TG in 23 (9.9%) and both antibodies in 23 (9.9%) patients. Thyroid antibodies presented early within the first 5 years of the onset of diabetes (63.2 vs. 36.8%, p < 0.05). The prevalence of elevated thyroid antibodies increased after the onset of puberty in both females and males (p < 0.0001). A total of 58.7% of the patients with positive antibodies were females compared to 41% males (p < 0.0001). The basal thyroid-stimulating hormone was higher in subjects with positive antibodies (5.1 ± 10.7 mIU/l) compared to those who were antibody negative (1.79 ± 0.87 mIU/l, p < 0.001). Furthermore, 30 out of 232 (12.9%) patients developed thyroid dysfunction. Conclusion: In this study, a high prevalence of thyroid autoimmune antibodies was found in patients either at the onset of type 1 diabetes or within the 4-9 years of follow-up.

KW - Anti-thyroglobulin

KW - Anti-thyroid peroxidase

KW - Thyroid autoimmune prevalence

KW - Thyroid dysfunction

KW - Type 1 diabetes

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