Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta-analysis

Ussama M. Abdel-Motal, G. Akila, Essam Mohamed, Chinnaiyan Ponnuraja, Khadija Iken, Mohamed Jahromi, George Priya Doss, Rajaa El Bekay, Hatem Zayed

Research output: Contribution to journalReview article

Abstract

The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics. Publication bias was assessed using the funnel-plot test. Our search strategy captured 372 studies in only 10 out of the 22 Arab countries in a period of 48 years (1969-2017); of which, 41 met our inclusion criteria for full article analysis, of those, 15 were eligible for meta-analysis. We estimated the prevalence of DN among Arab people with T1D to be 18.2% (95% confidence interval 13.1%-24.8%). In conclusion, DN prevalence is underexplored among Arab patients with T1D and represents a significant risk for the well-being of Arab patients with T1D. Therefore, there is an urgent need for comprehensive epidemiological studies for DN among Arab patients with T1D.

Original languageEnglish
Article numbere3026
JournalDiabetes/Metabolism Research and Reviews
Volume34
Issue number7
DOIs
Publication statusPublished - 1 Oct 2018

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Keywords

  • Arab populations
  • diabetic nephropathy
  • kidney disease
  • prevalence
  • type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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