Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar

Georgios Ponirakis, Tarik Elhadd, Subitha Chinnaiyan, Zeinab Dabbous, Mashhood Siddiqui, Hamad Al-muhannadi, Ioannis Petropoulos, Adnan Khan, Khaled A.E. Ashawesh, Khaled M.O. Dukhan, Ziyad R. Mahfoud, Christopher Murgatroyd, Mark Slevin, Rayaz A. Malik

Research output: Contribution to journalArticle

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Abstract

Aims/Introduction: Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the prevalence of PDPN and its associated factors in type 2 diabetes mellitus patients attending secondary care in Qatar. Materials and Methods: This was a cross-sectional study of 1,095 participants with type 2 diabetes mellitus attending Qatar's two national diabetes centers. PDPN and impaired vibration perception on the pulp of the large toes were assessed using the Douleur Neuropathique en 4 questionnaire with a cut-off ≥4 and the neurothesiometer with a cut-off ≥15 V, respectively. Results: The prevalence of PDPN was 34.5% (95% confidence interval [CI] 31.7–37.3), but 80% of these patients had not previously been diagnosed or treated for this condition. Arabs had a higher prevalence of PDPN compared with South Asians (P < 0.05). PDPN was associated with impaired vibration perception adjusted odds ratio (AOR) 4.42 (95% CI 2.92–6.70), smoking AOR 2.43 (95% CI 1.43–4.15), obesity AOR 1.74 (95% CI 1.13–2.66), being female AOR 1.65 (95% CI: 1.03–2.64) and duration of diabetes AOR 1.08 (95% CI 1.05–1.11). Age, poor glycemic control, hypertension, physical activity and proteinuria showed no association with PDPN. Conclusions: PDPN occurs in one-third of type 2 diabetes mellitus patients attending secondary care in Qatar, but the majority have not been diagnosed. Arabs are at higher risk for PDPN. Impaired vibration perception, obesity and smoking are associated with PDPN in Qatar.

Original languageEnglish
Pages (from-to)1558-1564
Number of pages7
JournalJournal of Diabetes Investigation
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Nov 2019

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Qatar
Diabetic Neuropathies
Peripheral Nervous System Diseases
Delivery of Health Care
Confidence Intervals
Odds Ratio
Vibration
Secondary Care
Diabetes Mellitus
Obesity
Smoking
Northern Africa
Eastern Africa
Middle East
Toes
Proteinuria

Keywords

  • Obesity
  • Painful diabetic peripheral neuropathy
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar. / Ponirakis, Georgios; Elhadd, Tarik; Chinnaiyan, Subitha; Dabbous, Zeinab; Siddiqui, Mashhood; Al-muhannadi, Hamad; Petropoulos, Ioannis; Khan, Adnan; Ashawesh, Khaled A.E.; Dukhan, Khaled M.O.; Mahfoud, Ziyad R.; Murgatroyd, Christopher; Slevin, Mark; Malik, Rayaz A.

In: Journal of Diabetes Investigation, Vol. 10, No. 6, 01.11.2019, p. 1558-1564.

Research output: Contribution to journalArticle

Ponirakis, G, Elhadd, T, Chinnaiyan, S, Dabbous, Z, Siddiqui, M, Al-muhannadi, H, Petropoulos, I, Khan, A, Ashawesh, KAE, Dukhan, KMO, Mahfoud, ZR, Murgatroyd, C, Slevin, M & Malik, RA 2019, 'Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar', Journal of Diabetes Investigation, vol. 10, no. 6, pp. 1558-1564. https://doi.org/10.1111/jdi.13037
Ponirakis, Georgios ; Elhadd, Tarik ; Chinnaiyan, Subitha ; Dabbous, Zeinab ; Siddiqui, Mashhood ; Al-muhannadi, Hamad ; Petropoulos, Ioannis ; Khan, Adnan ; Ashawesh, Khaled A.E. ; Dukhan, Khaled M.O. ; Mahfoud, Ziyad R. ; Murgatroyd, Christopher ; Slevin, Mark ; Malik, Rayaz A. / Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar. In: Journal of Diabetes Investigation. 2019 ; Vol. 10, No. 6. pp. 1558-1564.
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abstract = "Aims/Introduction: Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the prevalence of PDPN and its associated factors in type 2 diabetes mellitus patients attending secondary care in Qatar. Materials and Methods: This was a cross-sectional study of 1,095 participants with type 2 diabetes mellitus attending Qatar's two national diabetes centers. PDPN and impaired vibration perception on the pulp of the large toes were assessed using the Douleur Neuropathique en 4 questionnaire with a cut-off ≥4 and the neurothesiometer with a cut-off ≥15 V, respectively. Results: The prevalence of PDPN was 34.5{\%} (95{\%} confidence interval [CI] 31.7–37.3), but 80{\%} of these patients had not previously been diagnosed or treated for this condition. Arabs had a higher prevalence of PDPN compared with South Asians (P < 0.05). PDPN was associated with impaired vibration perception adjusted odds ratio (AOR) 4.42 (95{\%} CI 2.92–6.70), smoking AOR 2.43 (95{\%} CI 1.43–4.15), obesity AOR 1.74 (95{\%} CI 1.13–2.66), being female AOR 1.65 (95{\%} CI: 1.03–2.64) and duration of diabetes AOR 1.08 (95{\%} CI 1.05–1.11). Age, poor glycemic control, hypertension, physical activity and proteinuria showed no association with PDPN. Conclusions: PDPN occurs in one-third of type 2 diabetes mellitus patients attending secondary care in Qatar, but the majority have not been diagnosed. Arabs are at higher risk for PDPN. Impaired vibration perception, obesity and smoking are associated with PDPN in Qatar.",
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T1 - Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar

AU - Ponirakis, Georgios

AU - Elhadd, Tarik

AU - Chinnaiyan, Subitha

AU - Dabbous, Zeinab

AU - Siddiqui, Mashhood

AU - Al-muhannadi, Hamad

AU - Petropoulos, Ioannis

AU - Khan, Adnan

AU - Ashawesh, Khaled A.E.

AU - Dukhan, Khaled M.O.

AU - Mahfoud, Ziyad R.

AU - Murgatroyd, Christopher

AU - Slevin, Mark

AU - Malik, Rayaz A.

PY - 2019/11/1

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N2 - Aims/Introduction: Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the prevalence of PDPN and its associated factors in type 2 diabetes mellitus patients attending secondary care in Qatar. Materials and Methods: This was a cross-sectional study of 1,095 participants with type 2 diabetes mellitus attending Qatar's two national diabetes centers. PDPN and impaired vibration perception on the pulp of the large toes were assessed using the Douleur Neuropathique en 4 questionnaire with a cut-off ≥4 and the neurothesiometer with a cut-off ≥15 V, respectively. Results: The prevalence of PDPN was 34.5% (95% confidence interval [CI] 31.7–37.3), but 80% of these patients had not previously been diagnosed or treated for this condition. Arabs had a higher prevalence of PDPN compared with South Asians (P < 0.05). PDPN was associated with impaired vibration perception adjusted odds ratio (AOR) 4.42 (95% CI 2.92–6.70), smoking AOR 2.43 (95% CI 1.43–4.15), obesity AOR 1.74 (95% CI 1.13–2.66), being female AOR 1.65 (95% CI: 1.03–2.64) and duration of diabetes AOR 1.08 (95% CI 1.05–1.11). Age, poor glycemic control, hypertension, physical activity and proteinuria showed no association with PDPN. Conclusions: PDPN occurs in one-third of type 2 diabetes mellitus patients attending secondary care in Qatar, but the majority have not been diagnosed. Arabs are at higher risk for PDPN. Impaired vibration perception, obesity and smoking are associated with PDPN in Qatar.

AB - Aims/Introduction: Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the prevalence of PDPN and its associated factors in type 2 diabetes mellitus patients attending secondary care in Qatar. Materials and Methods: This was a cross-sectional study of 1,095 participants with type 2 diabetes mellitus attending Qatar's two national diabetes centers. PDPN and impaired vibration perception on the pulp of the large toes were assessed using the Douleur Neuropathique en 4 questionnaire with a cut-off ≥4 and the neurothesiometer with a cut-off ≥15 V, respectively. Results: The prevalence of PDPN was 34.5% (95% confidence interval [CI] 31.7–37.3), but 80% of these patients had not previously been diagnosed or treated for this condition. Arabs had a higher prevalence of PDPN compared with South Asians (P < 0.05). PDPN was associated with impaired vibration perception adjusted odds ratio (AOR) 4.42 (95% CI 2.92–6.70), smoking AOR 2.43 (95% CI 1.43–4.15), obesity AOR 1.74 (95% CI 1.13–2.66), being female AOR 1.65 (95% CI: 1.03–2.64) and duration of diabetes AOR 1.08 (95% CI 1.05–1.11). Age, poor glycemic control, hypertension, physical activity and proteinuria showed no association with PDPN. Conclusions: PDPN occurs in one-third of type 2 diabetes mellitus patients attending secondary care in Qatar, but the majority have not been diagnosed. Arabs are at higher risk for PDPN. Impaired vibration perception, obesity and smoking are associated with PDPN in Qatar.

KW - Obesity

KW - Painful diabetic peripheral neuropathy

KW - Type 2 diabetes

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