Presumed assault or accommodative reactions involved in human renal transplantation

M. Suthanthiran, R. R. Riggio, J. S. Cheigh, A. Walle, M. Fotino, K. H. Stenzel

Research output: Contribution to journalArticle

Abstract

The concept that allograft loss is secondary to immune assault mechanisms and graft success is simply due to abatement of such graft-destructive forces represents a reductive viewpoint of the complex immune processes that are involved in allograft rejection. The immunologically dominated fate of renal allografts appears to rest on the delicate balance between mutually opposing graft-destructive and graft-protective immune mechanisms unleashed by the host following the perception of potent stimulatory signals originated by the allograft. Activated cells and their secretory products, responsible for the irrevocable destruction of the allograft and immune circuits that are pivotal to the generation of graft-adaptive immune responses, are being rapidly identified.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalRenal Failure
Volume8
Issue number3-4
DOIs
Publication statusPublished - 1 Jan 1984

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ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

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