Background: Hepaguard is a polyherbal formulation consisting of Thespesia populnea and Embilica officinalis. Previous reports indicate that Thespesia populnea has antioxidant and wound healing activities. However, hepatoprotective activity of Hepaguard has not been studied yet. Methods: Hepatoprotective activity of Hepaguard was studied in ethanol -induced hepatic damage in Wistar albino rats by determining relevant biochemical parameters in serum and tissue. In serum, the activities of liver marker enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), and concentrations of bilirubin, protein and lipids were evaluated. In liver, the concentrations of total cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) were determined. Results: Oral administration of Hepaguard (20 mg/kg) for 60 days significantly reduced the toxic effects of ethanol. Its efficacy was comparable with that of Picroliv. Conclusion: These observations suggest that Hepaguard protects the liver against the toxic effects of ethanol.
|Number of pages||5|
|Publication status||Published - Jan 2007|
- Hepatic markers
- Herbal formulation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)