Preliminary evaluation of hepatoprotective effect of Hepaguard against alcohol induced hepatic damage in rats

P. Yuvaraj, Therasilin Louis, Basirudeen S. Kabeer, V. Madhavachandran

Research output: Contribution to journalArticle

Abstract

Background: Hepaguard is a polyherbal formulation consisting of Thespesia populnea and Embilica officinalis. Previous reports indicate that Thespesia populnea has antioxidant and wound healing activities. However, hepatoprotective activity of Hepaguard has not been studied yet. Methods: Hepatoprotective activity of Hepaguard was studied in ethanol -induced hepatic damage in Wistar albino rats by determining relevant biochemical parameters in serum and tissue. In serum, the activities of liver marker enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), and concentrations of bilirubin, protein and lipids were evaluated. In liver, the concentrations of total cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) were determined. Results: Oral administration of Hepaguard (20 mg/kg) for 60 days significantly reduced the toxic effects of ethanol. Its efficacy was comparable with that of Picroliv. Conclusion: These observations suggest that Hepaguard protects the liver against the toxic effects of ethanol.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalBiomedicine
Volume27
Issue number1
Publication statusPublished - Jan 2007
Externally publishedYes

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Keywords

  • Alcohol
  • Hepatic markers
  • Hepatoprotection
  • Herbal formulation
  • Lipids
  • Rats

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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