Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas

P. Mérel, K. Hoang‐Xuan, M. Sanson, A. Moreau‐Aubry, E. K. Bijlsma, C. Lazaro, J. P. Moisan, F. Resche, I. Nishisho, Xavier P. Estivill, J. Y. Delattre, M. Poisson, C. Theillet, T. Hulsebos, O. Delattre, G. Thomas

Research output: Contribution to journalArticle

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Abstract

The NF2 gene is a putative tumor‐suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor‐susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the NF2 gene on chromosome 22 allows the identification of somatic mutations in human tumors. We have searched for mutations of the NF2 gene in 331 primary human tumors using a screening method based on denaturing gradient gel electrophoresis, which allows the detection of mutations in 95% of the coding sequence. Mutations were observed in 17 of 57 meningiomas and in 30 of 89 schwannomas. No mutations were observed for 17 ependymomas, 70 gliomas, 23 primary melanomas, 24 pheochromocytomas, 15 neuroblastomas, 6 medulloblastomas, 15 colon cancers, and 15 breast cancers. All meningiomas and one‐half of the schwannomas with identified NF2 mutations demonstrated chromosome 22 allelic losses. We conclude that the involvement of the NF2 gene in human tumorigenesis may be restricted to schwannomas and meningiomas, where it is frequently inactivated by a two‐hit process. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalGenes, Chromosomes and Cancer
Volume13
Issue number3
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Neurilemmoma
Meningioma
Mutation
Genes
Chromosomes, Human, Pair 22
Neurofibromatosis 2
Breast Neoplasms
Ependymoma
Denaturing Gradient Gel Electrophoresis
Medulloblastoma
Loss of Heterozygosity
Pheochromocytoma
Neuroblastoma
Glioma
Colonic Neoplasms
Melanoma
Neoplasms
Carcinogenesis

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Mérel, P., Hoang‐Xuan, K., Sanson, M., Moreau‐Aubry, A., Bijlsma, E. K., Lazaro, C., ... Thomas, G. (1995). Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Genes, Chromosomes and Cancer, 13(3), 211-216. https://doi.org/10.1002/gcc.2870130311

Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. / Mérel, P.; Hoang‐Xuan, K.; Sanson, M.; Moreau‐Aubry, A.; Bijlsma, E. K.; Lazaro, C.; Moisan, J. P.; Resche, F.; Nishisho, I.; Estivill, Xavier P.; Delattre, J. Y.; Poisson, M.; Theillet, C.; Hulsebos, T.; Delattre, O.; Thomas, G.

In: Genes, Chromosomes and Cancer, Vol. 13, No. 3, 1995, p. 211-216.

Research output: Contribution to journalArticle

Mérel, P, Hoang‐Xuan, K, Sanson, M, Moreau‐Aubry, A, Bijlsma, EK, Lazaro, C, Moisan, JP, Resche, F, Nishisho, I, Estivill, XP, Delattre, JY, Poisson, M, Theillet, C, Hulsebos, T, Delattre, O & Thomas, G 1995, 'Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas', Genes, Chromosomes and Cancer, vol. 13, no. 3, pp. 211-216. https://doi.org/10.1002/gcc.2870130311
Mérel P, Hoang‐Xuan K, Sanson M, Moreau‐Aubry A, Bijlsma EK, Lazaro C et al. Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Genes, Chromosomes and Cancer. 1995;13(3):211-216. https://doi.org/10.1002/gcc.2870130311
Mérel, P. ; Hoang‐Xuan, K. ; Sanson, M. ; Moreau‐Aubry, A. ; Bijlsma, E. K. ; Lazaro, C. ; Moisan, J. P. ; Resche, F. ; Nishisho, I. ; Estivill, Xavier P. ; Delattre, J. Y. ; Poisson, M. ; Theillet, C. ; Hulsebos, T. ; Delattre, O. ; Thomas, G. / Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. In: Genes, Chromosomes and Cancer. 1995 ; Vol. 13, No. 3. pp. 211-216.
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