Predicting protein folding pathways

Mohammed J. Zaki, Vinay Nadimpally, Deb Bardhan, Chris Bystroff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A structured folding pathway, which is a time ordered sequence of folding events, plays an important role in the protein folding process and hence, in the conformational search. Pathway prediction, thus gives more insight into the folding process and is a valuable guiding tool to search the conformation space. In this paper, we propose a novel 'unfolding' approach to predict the folding pathway. We apply graph-based methods on a weighted secondary structure graph of a protein to predict the sequence of unfolding events. When viewed in reverse this yields the folding pathway. We demonstrate the success of our approach on several proteins whose pathway is partially known.

Original languageEnglish
JournalBioinformatics
Volume20
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1 Dec 2004
Externally publishedYes

Fingerprint

Protein folding
Protein Folding
Folding
Pathway
Proteins
Conformations
Unfolding
Protein
Predict
Secondary Structure
Graph in graph theory
Conformation
Reverse
Prediction
Demonstrate

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Zaki, M. J., Nadimpally, V., Bardhan, D., & Bystroff, C. (2004). Predicting protein folding pathways. Bioinformatics, 20(SUPPL. 1). https://doi.org/10.1093/bioinformatics/bth935

Predicting protein folding pathways. / Zaki, Mohammed J.; Nadimpally, Vinay; Bardhan, Deb; Bystroff, Chris.

In: Bioinformatics, Vol. 20, No. SUPPL. 1, 01.12.2004.

Research output: Contribution to journalArticle

Zaki, MJ, Nadimpally, V, Bardhan, D & Bystroff, C 2004, 'Predicting protein folding pathways', Bioinformatics, vol. 20, no. SUPPL. 1. https://doi.org/10.1093/bioinformatics/bth935
Zaki MJ, Nadimpally V, Bardhan D, Bystroff C. Predicting protein folding pathways. Bioinformatics. 2004 Dec 1;20(SUPPL. 1). https://doi.org/10.1093/bioinformatics/bth935
Zaki, Mohammed J. ; Nadimpally, Vinay ; Bardhan, Deb ; Bystroff, Chris. / Predicting protein folding pathways. In: Bioinformatics. 2004 ; Vol. 20, No. SUPPL. 1.
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