Prediabetes and diabetes in a cohort of Qatari women screened for polycystic ovary syndrome

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM) but its association with prediabetes and T2DM is unknown in Qatar. A cross sectional analysis of 3,017 Qatari subjects from the Qatar Biobank, identified 749 women aged 18-40 years, 720 of whom were assessed by the National Institute for Health (NIH) Guidelines for PCOS. Prediabetes (HbA1c 5.7-6.4% and/or impaired fasting glucose (IFG): fasting plasma glucose (FPG) 100-125 mg/dL (5.6-6.9 mmol/L)), and T2DM (fasting plasma glucose > 125 mg/dL (≥7 mmol/L), and/or HbA1c ≥ 6.5%) were determined. The prevalence of prediabetes was 10.6% and the prevalence of undiagnosed diabetes was found to be 4.0% in the total population. Overall, 12.1% of 720 women had PCOS, of whom FPG and HbA1c were available in 62 women with PCOS: 19.4% had prediabetes and 9.7% had diabetes. An adverse cardiovascular risk profile for IFG women compared to normal women was found. Women with PCOS alone had a similar adverse cardiovascular profile as those with IFG alone and T2DM. Thus, the risk of prediabetes and diabetes is increased in Qatari women with PCOS, with an adverse cardiovascular risk profile similar to that seen in prediabetes and T2DM.

Original languageEnglish
Article number3619
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

Prediabetic State
Polycystic Ovary Syndrome
Fasting
Type 2 Diabetes Mellitus
Glucose
Qatar
National Institutes of Health (U.S.)
Cross-Sectional Studies
Guidelines
Population

ASJC Scopus subject areas

  • General

Cite this

@article{fbd5053c30894a168f0d1bd4347fa6a4,
title = "Prediabetes and diabetes in a cohort of Qatari women screened for polycystic ovary syndrome",
abstract = "Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM) but its association with prediabetes and T2DM is unknown in Qatar. A cross sectional analysis of 3,017 Qatari subjects from the Qatar Biobank, identified 749 women aged 18-40 years, 720 of whom were assessed by the National Institute for Health (NIH) Guidelines for PCOS. Prediabetes (HbA1c 5.7-6.4{\%} and/or impaired fasting glucose (IFG): fasting plasma glucose (FPG) 100-125 mg/dL (5.6-6.9 mmol/L)), and T2DM (fasting plasma glucose > 125 mg/dL (≥7 mmol/L), and/or HbA1c ≥ 6.5{\%}) were determined. The prevalence of prediabetes was 10.6{\%} and the prevalence of undiagnosed diabetes was found to be 4.0{\%} in the total population. Overall, 12.1{\%} of 720 women had PCOS, of whom FPG and HbA1c were available in 62 women with PCOS: 19.4{\%} had prediabetes and 9.7{\%} had diabetes. An adverse cardiovascular risk profile for IFG women compared to normal women was found. Women with PCOS alone had a similar adverse cardiovascular profile as those with IFG alone and T2DM. Thus, the risk of prediabetes and diabetes is increased in Qatari women with PCOS, with an adverse cardiovascular risk profile similar to that seen in prediabetes and T2DM.",
author = "Soha Dargham and Abeer Elshewehy and Youssra Dakroury and Kilpatrick, {Eric S.} and Stephen Atkin",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-21987-6",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Prediabetes and diabetes in a cohort of Qatari women screened for polycystic ovary syndrome

AU - Dargham, Soha

AU - Elshewehy, Abeer

AU - Dakroury, Youssra

AU - Kilpatrick, Eric S.

AU - Atkin, Stephen

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM) but its association with prediabetes and T2DM is unknown in Qatar. A cross sectional analysis of 3,017 Qatari subjects from the Qatar Biobank, identified 749 women aged 18-40 years, 720 of whom were assessed by the National Institute for Health (NIH) Guidelines for PCOS. Prediabetes (HbA1c 5.7-6.4% and/or impaired fasting glucose (IFG): fasting plasma glucose (FPG) 100-125 mg/dL (5.6-6.9 mmol/L)), and T2DM (fasting plasma glucose > 125 mg/dL (≥7 mmol/L), and/or HbA1c ≥ 6.5%) were determined. The prevalence of prediabetes was 10.6% and the prevalence of undiagnosed diabetes was found to be 4.0% in the total population. Overall, 12.1% of 720 women had PCOS, of whom FPG and HbA1c were available in 62 women with PCOS: 19.4% had prediabetes and 9.7% had diabetes. An adverse cardiovascular risk profile for IFG women compared to normal women was found. Women with PCOS alone had a similar adverse cardiovascular profile as those with IFG alone and T2DM. Thus, the risk of prediabetes and diabetes is increased in Qatari women with PCOS, with an adverse cardiovascular risk profile similar to that seen in prediabetes and T2DM.

AB - Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM) but its association with prediabetes and T2DM is unknown in Qatar. A cross sectional analysis of 3,017 Qatari subjects from the Qatar Biobank, identified 749 women aged 18-40 years, 720 of whom were assessed by the National Institute for Health (NIH) Guidelines for PCOS. Prediabetes (HbA1c 5.7-6.4% and/or impaired fasting glucose (IFG): fasting plasma glucose (FPG) 100-125 mg/dL (5.6-6.9 mmol/L)), and T2DM (fasting plasma glucose > 125 mg/dL (≥7 mmol/L), and/or HbA1c ≥ 6.5%) were determined. The prevalence of prediabetes was 10.6% and the prevalence of undiagnosed diabetes was found to be 4.0% in the total population. Overall, 12.1% of 720 women had PCOS, of whom FPG and HbA1c were available in 62 women with PCOS: 19.4% had prediabetes and 9.7% had diabetes. An adverse cardiovascular risk profile for IFG women compared to normal women was found. Women with PCOS alone had a similar adverse cardiovascular profile as those with IFG alone and T2DM. Thus, the risk of prediabetes and diabetes is increased in Qatari women with PCOS, with an adverse cardiovascular risk profile similar to that seen in prediabetes and T2DM.

UR - http://www.scopus.com/inward/record.url?scp=85042677792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042677792&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-21987-6

DO - 10.1038/s41598-018-21987-6

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3619

ER -