Pre- and post- prandial appetite hormone levels in normal weight and severely obese women

Joseph J. Carlson, Amy A. Turpin, Gail Wiebke, Steven Hunt, Ted D. Adams

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Appetite is affected by many factors including the hormones leptin, ghrelin and adiponectin. Ghrelin stimulates hunger, leptin promotes satiety, and adiponectin affects insulin response. This study was designed to test whether the pre- and postprandial response of key appetite hormones differs in normal weight (NW) and severely obese (SO) women. Methods. Twenty three women ages 2550 were recruited for this study including 10 NW (BMI = 23.1 1.3 kg/m2) and 13 SO (BMI = 44.5 7.1 kg/m2). The study was conducted in a hospital-based clinical research centre. Following a 12-hour fast, participants had a baseline blood draw, consumed a moderately high carbohydrate meal (60% carbohydrate, 20% protein, 20% fat) based on body weight. Postprandially, participants had six blood samples drawn at 0, 15, 30, 60, 90, and 120 minutes. Primary measures included pre- and post-prandial total ghrelin, leptin, adiponectin and insulin. A repeated measures general linear model was used to evaluate the hormone changes by group and time (significance p 0.05). Results. There were significant differences between the NW and the SO for all hormones in the preprandial fasting state. The postprandial responses between the SO versus NW revealed: higher leptin (p < 0.0001), lower adiponectin (p = 0.04), trend for lower ghrelin (p = 0.06) and insulin was not different (p = 0.26). Postprandial responses over time between the SO versus NW: higher leptin (p < 0.001), lower ghrelin and adiponectin (p = 0.004, p = 0.015, respectively), and trend for higher insulin (p = 0.06). Conclusion. This study indicates that significant differences in both pre- and selected post- prandial levels of leptin, ghrelin, adiponectin and insulin exist between NW and SO women. Improving our understanding of the biochemical mechanisms accounting for these differences in appetite hormones among individuals with varying body size and adiposity should aid in the development of future therapies to prevent and treat obesity.

Original languageEnglish
Article number32
JournalNutrition and Metabolism
Volume6
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Ghrelin
Adiponectin
Appetite
Leptin
Meals
Hormones
Weights and Measures
Insulin
Carbohydrates
Hunger
Adiposity
Body Size
Linear Models
Fasting
Obesity
Fats
Body Weight
Research
Proteins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Pre- and post- prandial appetite hormone levels in normal weight and severely obese women. / Carlson, Joseph J.; Turpin, Amy A.; Wiebke, Gail; Hunt, Steven; Adams, Ted D.

In: Nutrition and Metabolism, Vol. 6, 32, 2009.

Research output: Contribution to journalArticle

Carlson, Joseph J. ; Turpin, Amy A. ; Wiebke, Gail ; Hunt, Steven ; Adams, Ted D. / Pre- and post- prandial appetite hormone levels in normal weight and severely obese women. In: Nutrition and Metabolism. 2009 ; Vol. 6.
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