Possible locus on chromosome 18q influencing postural systolic blood pressure changes

James S. Pankow, Kathryn M. Rose, Albert Oberman, Steven Hunt, Larry D. Atwood, Luc Djoussé, Michael A. Province, D. C. Rao

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We conducted a genome-wide scan for quantitative trait loci influencing the systolic blood pressure, diastolic blood pressure, and pulse responses to a postural challenge in 498 white sibling-pairs from the Hypertension Genetic Epidemiology Network, a multicenter study of the genetic susceptibility to hypertension. All participants were hypertensive (systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or on antihypertensive medications) with diagnosis before age 60. Blood pressure and pulse were measured by an oscillometric method after a 5-minute rest in a supine position and again immediately on standing. The genome scan included a total of 387 autosomal short-tandem-repeat polymorphisms typed by the National Heart, Lung, and Blood Institute Mammalian Genotyping Service at Marshfield. We used multipoint variance-components linkage analysis to identify possible quantitative trait loci influencing postural change phenotypes after adjusting for sex, age, and use of antihypertensive medications. There was suggestive evidence for linkage on chromosome 18q for the postural systolic blood pressure response (maximum logarithm of the odds score=2.6 at 80 centiMorgans). We also observed a maximum logarithm of the odds score of 1.9 for the systolic blood pressure response and 1.7 for the diastolic blood pressure response on chromosome 6p. The marker that demonstrated the strongest evidence for linkage for the systolic blood pressure response (D18S858) lies within 20 centiMorgans of a marker previously linked to rare familial orthostatic hypotensive syndrome. Our findings indicate that there may be 1 or more genes on chromosome 18q that regulate systolic blood pressure during the physiological recovery period after a postural stressor.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalHypertension
Volume36
Issue number4
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Chromosomes
Blood Pressure
Quantitative Trait Loci
Antihypertensive Agents
Genome
Hypertension
National Heart, Lung, and Blood Institute (U.S.)
Molecular Epidemiology
Supine Position
Genetic Predisposition to Disease
Microsatellite Repeats
Multicenter Studies

Keywords

  • Blood pressure
  • Chromosome mapping
  • Heart rate
  • Hypertension
  • Linkage
  • Posture

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Pankow, J. S., Rose, K. M., Oberman, A., Hunt, S., Atwood, L. D., Djoussé, L., ... Rao, D. C. (2000). Possible locus on chromosome 18q influencing postural systolic blood pressure changes. Hypertension, 36(4), 471-476.

Possible locus on chromosome 18q influencing postural systolic blood pressure changes. / Pankow, James S.; Rose, Kathryn M.; Oberman, Albert; Hunt, Steven; Atwood, Larry D.; Djoussé, Luc; Province, Michael A.; Rao, D. C.

In: Hypertension, Vol. 36, No. 4, 2000, p. 471-476.

Research output: Contribution to journalArticle

Pankow, JS, Rose, KM, Oberman, A, Hunt, S, Atwood, LD, Djoussé, L, Province, MA & Rao, DC 2000, 'Possible locus on chromosome 18q influencing postural systolic blood pressure changes', Hypertension, vol. 36, no. 4, pp. 471-476.
Pankow JS, Rose KM, Oberman A, Hunt S, Atwood LD, Djoussé L et al. Possible locus on chromosome 18q influencing postural systolic blood pressure changes. Hypertension. 2000;36(4):471-476.
Pankow, James S. ; Rose, Kathryn M. ; Oberman, Albert ; Hunt, Steven ; Atwood, Larry D. ; Djoussé, Luc ; Province, Michael A. ; Rao, D. C. / Possible locus on chromosome 18q influencing postural systolic blood pressure changes. In: Hypertension. 2000 ; Vol. 36, No. 4. pp. 471-476.
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