Porphyrinic Metal-Organic Frameworks Installed with Brønsted Acid Sites for Efficient Tandem Semisynthesis of Artemisinin

Liang Feng, Ying Wang, Shuai Yuan, Kun Yu Wang, Jia Luo Li, Gregory S. Day, Di Qiu, Lin Cheng, Wen Miao Chen, Sherzod Madrahimov, Hong Cai Zhou

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Artemisinin, an essential antimalarial drug, requires a synthetic pathway that has a high environmental and financial cost. Conventional homogeneous photocatalysts and acid catalysts usually suffer from recycling problems that lead to a dramatic decrease in catalytic activity, while current heterogeneous catalysts with low surface areas are limited by issues such as active-site accessibility and precise reaction tailorability. Herein, we report the successful installation of Brønsted acid sites into a series of porphyrinic metal-organic frameworks (MOFs) that feature large channels, high surface areas, and tailored pore environments for catalysis via a postsynthetic installation strategy. Accordingly, the resulting dual-function solid acid/photocatalyst can be utilized for the tandem semisynthesis of artemisinin from dihydroartemisinic acid and demonstrates efficient catalytic performance. It is worth noting that this dual-functionalized nanoreactor acts as the most efficient catalyst for artemisinin production among all known homogeneous and heterogeneous photocatalysts. The facile heterogeneous catalytic system can be efficiently recycled, showing enhanced stability in comparison to the traditional homogeneous catalysts. The result highlights the advantage of the hierarchically porous MOF catalyst with tailored functionalities and cooperative motifs as a highly accessible and recyclable heterogeneous catalyst, providing a more efficient and recyclable approach to drug production.

Original languageEnglish
Pages (from-to)5111-5118
Number of pages8
JournalACS Catalysis
Volume9
Issue number6
DOIs
Publication statusPublished - 7 Jun 2019

Fingerprint

Metals
Catalysts
Acids
Photocatalysts
Nanoreactors
Antimalarials
Catalysis
artemisinine
Recycling
Catalyst activity
Pharmaceutical Preparations
Costs

Keywords

  • artemisinin
  • Brønsted acid catalysis
  • mesoporous materials
  • metal-organic frameworks
  • photocatalysis
  • recyclability
  • tandem heterogeneous catalysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Porphyrinic Metal-Organic Frameworks Installed with Brønsted Acid Sites for Efficient Tandem Semisynthesis of Artemisinin. / Feng, Liang; Wang, Ying; Yuan, Shuai; Wang, Kun Yu; Li, Jia Luo; Day, Gregory S.; Qiu, Di; Cheng, Lin; Chen, Wen Miao; Madrahimov, Sherzod; Zhou, Hong Cai.

In: ACS Catalysis, Vol. 9, No. 6, 07.06.2019, p. 5111-5118.

Research output: Contribution to journalArticle

Feng, L, Wang, Y, Yuan, S, Wang, KY, Li, JL, Day, GS, Qiu, D, Cheng, L, Chen, WM, Madrahimov, S & Zhou, HC 2019, 'Porphyrinic Metal-Organic Frameworks Installed with Brønsted Acid Sites for Efficient Tandem Semisynthesis of Artemisinin', ACS Catalysis, vol. 9, no. 6, pp. 5111-5118. https://doi.org/10.1021/acscatal.8b04960
Feng, Liang ; Wang, Ying ; Yuan, Shuai ; Wang, Kun Yu ; Li, Jia Luo ; Day, Gregory S. ; Qiu, Di ; Cheng, Lin ; Chen, Wen Miao ; Madrahimov, Sherzod ; Zhou, Hong Cai. / Porphyrinic Metal-Organic Frameworks Installed with Brønsted Acid Sites for Efficient Tandem Semisynthesis of Artemisinin. In: ACS Catalysis. 2019 ; Vol. 9, No. 6. pp. 5111-5118.
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