Polyvinyl alcohol functionalized cobalt ferrite nanoparticles for biomedical applications

A. B. Salunkhe, V. M. Khot, N. D. Thorat, M. R. Phadatare, C. I. Sathish, Dattatray Dhawale, S. H. Pawar

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103 Citations (Scopus)


In the present work, cobalt ferrite nanoparticles (CoFe2O 4 NPs) have been synthesized by combustion method. The surface of the CoFe2O4 NPs was modified with biocompatible polyvinyl alcohol (PVA). To investigate effect and nature of coating on the surface of CoFe2O4 NPs, the NPs were characterized X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). The transmission electron microscopy (TEM) and dynamic light scattering (DLS) results demonstrate the monodispersed characteristics of CoFe2O4 NPs after surface modification with PVA. The decrease in contact angle from 162° to 50° with PVA coating on NPs indicates the transition from hydrophobic nature to hydrophilic. The Magnetic properties measurement system (MPMS) results show that the NPs have ferromagnetic behavior with high magnetization of 75.04 and 71.02 emu/g of uncoated and coated CoFe2O4 NPs respectively. These PVA coated NPs exhibit less toxicity over uncoated CoFe2O4 NPs up to 1.8 mg mL-1 when tested with mouse fibroblast L929 cell line.

Original languageEnglish
Pages (from-to)598-604
Number of pages7
JournalApplied Surface Science
Publication statusPublished - 1 Jan 2013
Externally publishedYes



  • CoFeO nanoparticles
  • Cytotoxicity
  • Magnetic diameter
  • Polyvinyl alcohol coatings

ASJC Scopus subject areas

  • Surfaces, Coatings and Films

Cite this

Salunkhe, A. B., Khot, V. M., Thorat, N. D., Phadatare, M. R., Sathish, C. I., Dhawale, D., & Pawar, S. H. (2013). Polyvinyl alcohol functionalized cobalt ferrite nanoparticles for biomedical applications. Applied Surface Science, 264, 598-604. https://doi.org/10.1016/j.apsusc.2012.10.073