Polymer-based non-viral gene delivery as a concept for the treatment of cancer

Anna Halama, Michał Kuliński, Tadeusz Librowski, Stanisław Lochyński

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Gene therapy has become a promising technique for the treatment of cancer. Nevertheless, the success of gene therapy depends on the effectiveness of the vector. The challenge of a gene carrier is to deliver exogenous DNAfrom the site of administration into the nucleus of the appropriate target cell. Polymer-based vectors are biologically safe, have low production costs and are efficient tools for gene therapy. Although non-degradable polyplexes exhibit high gene expression levels, their application potential is limited due to their inability to be effectively eliminated, which results in cytotoxicity. The development of biodegradable polymers has allowed for high levels of transfection without cytotoxicity. For site-specific targeting of polyplexes, further modifications, such as incorporation of ligands, can be performed. Most expectations have been addressed to polyplexes architecture according it dynamic response with the microenvironment.

Original languageEnglish
Pages (from-to)993-999
Number of pages7
JournalPharmacological Reports
Volume61
Issue number6
DOIs
Publication statusPublished - 1 Jan 2009
Externally publishedYes

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Keywords

  • Cancer
  • Gene delivery
  • Polymers
  • Polyplexes
  • Synthetic vectors

ASJC Scopus subject areas

  • Pharmacology

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