Plasmapheresis in a patient with angioimmunoblastic lymphadenopathy

Improvement in clinical and immunologic abnormalities

Bruce R. Gordon, Manikkam Suthanthiran, Stuart D. Saal, Kurt H. Stenzel, Albert L. Rubin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A patient with steroid resistant, allergen related angioimmunoblastic lymphadenopathy underwent a course of six plasmaphereses during a three‐week period. A 75% reduction in lymph node size along with the disappearance of her night sweats occurred. Immunologic abnormalities prior to plasmapheresis included the presence of elevated levels of circulating immune complexes, high levels of spontaneous mononuclear cell blastogenesis and abnormal mitogen responses to Conconavalin A and phytohemaglutinin. Following plasmapheresis there was a marked reduction in immune complex levels, and return of spontaneous blastogenesis and mitogen responses to normal levels. Mechanisms for the beneficial effect seen in this patient include removal of: (1) the antigenic stimulus; (2) antigen antibody complexes; and (3) other humoral factors which may modulate lymphocyte or macrophage function. Additional studies of plasmapheresis are warranted in selected patients with allergen related AIL.

Original languageEnglish
Pages (from-to)829-833
Number of pages5
JournalCancer
Volume51
Issue number5
DOIs
Publication statusPublished - 1 Jan 1983
Externally publishedYes

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Immunoblastic Lymphadenopathy
Plasmapheresis
Antigen-Antibody Complex
Lymphocyte Activation
Mitogens
Allergens
Sweat
Lymph Nodes
Macrophages
Steroids
Lymphocytes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Plasmapheresis in a patient with angioimmunoblastic lymphadenopathy : Improvement in clinical and immunologic abnormalities. / Gordon, Bruce R.; Suthanthiran, Manikkam; Saal, Stuart D.; Stenzel, Kurt H.; Rubin, Albert L.

In: Cancer, Vol. 51, No. 5, 01.01.1983, p. 829-833.

Research output: Contribution to journalArticle

Gordon, Bruce R. ; Suthanthiran, Manikkam ; Saal, Stuart D. ; Stenzel, Kurt H. ; Rubin, Albert L. / Plasmapheresis in a patient with angioimmunoblastic lymphadenopathy : Improvement in clinical and immunologic abnormalities. In: Cancer. 1983 ; Vol. 51, No. 5. pp. 829-833.
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