Plasma soluble α-klotho protein levels in premature and term neonates

Correlations with growth and metabolic parameters

Tania Siahanidou, Maria Garatzioti, Christina Lazaropoulou, Georgia Kourlaba, Ioannis Papassotiriou, Tomoshige Kino, Akihiro Imura, Yo Ichi Nabeshima, George Chrousos

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalEuropean Journal of Endocrinology
Volume167
Issue number3
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

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Oxidative Stress
Newborn Infant
Gestational Age
Growth
Vitamin D
Insulin
Malondialdehyde
Premature Infants
Insulin Resistance
Homeostasis
Enzyme-Linked Immunosorbent Assay
Body Weight
klotho protein
Prospective Studies
Bone and Bones
Glucose

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma soluble α-klotho protein levels in premature and term neonates : Correlations with growth and metabolic parameters. / Siahanidou, Tania; Garatzioti, Maria; Lazaropoulou, Christina; Kourlaba, Georgia; Papassotiriou, Ioannis; Kino, Tomoshige; Imura, Akihiro; Nabeshima, Yo Ichi; Chrousos, George.

In: European Journal of Endocrinology, Vol. 167, No. 3, 09.2012, p. 433-440.

Research output: Contribution to journalArticle

Siahanidou, T, Garatzioti, M, Lazaropoulou, C, Kourlaba, G, Papassotiriou, I, Kino, T, Imura, A, Nabeshima, YI & Chrousos, G 2012, 'Plasma soluble α-klotho protein levels in premature and term neonates: Correlations with growth and metabolic parameters', European Journal of Endocrinology, vol. 167, no. 3, pp. 433-440. https://doi.org/10.1530/EJE-12-0476
Siahanidou, Tania ; Garatzioti, Maria ; Lazaropoulou, Christina ; Kourlaba, Georgia ; Papassotiriou, Ioannis ; Kino, Tomoshige ; Imura, Akihiro ; Nabeshima, Yo Ichi ; Chrousos, George. / Plasma soluble α-klotho protein levels in premature and term neonates : Correlations with growth and metabolic parameters. In: European Journal of Endocrinology. 2012 ; Vol. 167, No. 3. pp. 433-440.
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abstract = "Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.",
author = "Tania Siahanidou and Maria Garatzioti and Christina Lazaropoulou and Georgia Kourlaba and Ioannis Papassotiriou and Tomoshige Kino and Akihiro Imura and Nabeshima, {Yo Ichi} and George Chrousos",
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T1 - Plasma soluble α-klotho protein levels in premature and term neonates

T2 - Correlations with growth and metabolic parameters

AU - Siahanidou, Tania

AU - Garatzioti, Maria

AU - Lazaropoulou, Christina

AU - Kourlaba, Georgia

AU - Papassotiriou, Ioannis

AU - Kino, Tomoshige

AU - Imura, Akihiro

AU - Nabeshima, Yo Ichi

AU - Chrousos, George

PY - 2012/9

Y1 - 2012/9

N2 - Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.

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