Plasma soluble α-klotho protein levels in premature and term neonates: Correlations with growth and metabolic parameters

Tania Siahanidou, Maria Garatzioti, Christina Lazaropoulou, Georgia Kourlaba, Ioannis Papassotiriou, Tomoshige Kino, Akihiro Imura, Yo Ichi Nabeshima, George Chrousos

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalEuropean Journal of Endocrinology
Volume167
Issue number3
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

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Oxidative Stress
Newborn Infant
Gestational Age
Growth
Vitamin D
Insulin
Malondialdehyde
Premature Infants
Insulin Resistance
Homeostasis
Enzyme-Linked Immunosorbent Assay
Body Weight
klotho protein
Prospective Studies
Bone and Bones
Glucose

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma soluble α-klotho protein levels in premature and term neonates : Correlations with growth and metabolic parameters. / Siahanidou, Tania; Garatzioti, Maria; Lazaropoulou, Christina; Kourlaba, Georgia; Papassotiriou, Ioannis; Kino, Tomoshige; Imura, Akihiro; Nabeshima, Yo Ichi; Chrousos, George.

In: European Journal of Endocrinology, Vol. 167, No. 3, 09.2012, p. 433-440.

Research output: Contribution to journalArticle

Siahanidou, T, Garatzioti, M, Lazaropoulou, C, Kourlaba, G, Papassotiriou, I, Kino, T, Imura, A, Nabeshima, YI & Chrousos, G 2012, 'Plasma soluble α-klotho protein levels in premature and term neonates: Correlations with growth and metabolic parameters', European Journal of Endocrinology, vol. 167, no. 3, pp. 433-440. https://doi.org/10.1530/EJE-12-0476
Siahanidou, Tania ; Garatzioti, Maria ; Lazaropoulou, Christina ; Kourlaba, Georgia ; Papassotiriou, Ioannis ; Kino, Tomoshige ; Imura, Akihiro ; Nabeshima, Yo Ichi ; Chrousos, George. / Plasma soluble α-klotho protein levels in premature and term neonates : Correlations with growth and metabolic parameters. In: European Journal of Endocrinology. 2012 ; Vol. 167, No. 3. pp. 433-440.
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abstract = "Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.",
author = "Tania Siahanidou and Maria Garatzioti and Christina Lazaropoulou and Georgia Kourlaba and Ioannis Papassotiriou and Tomoshige Kino and Akihiro Imura and Nabeshima, {Yo Ichi} and George Chrousos",
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T1 - Plasma soluble α-klotho protein levels in premature and term neonates

T2 - Correlations with growth and metabolic parameters

AU - Siahanidou, Tania

AU - Garatzioti, Maria

AU - Lazaropoulou, Christina

AU - Kourlaba, Georgia

AU - Papassotiriou, Ioannis

AU - Kino, Tomoshige

AU - Imura, Akihiro

AU - Nabeshima, Yo Ichi

AU - Chrousos, George

PY - 2012/9

Y1 - 2012/9

N2 - Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.

AB - Objective: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. Design: Prospective study. Methods: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (S.D.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. Results: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32, P=0.001), body weight (β=0.34, P=0.001), body length (β=0.33, P=0.001), 1,25-dihydroxy-vitamin D level (β=0.24, P<0.05), and malondialdehyde level (β=0.20, P<0.05) but not with glucose, insulin, or homeostasis model assessment index of insulin resistance values. Conclusions: Soluble α-KL levels rise as GA and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Whether α-KL may have a role in the regulation of infants' growth should be further studied.

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