Physically synthesized Ni-Cu nanoparticles for magnetic hyperthermia

Martin Bettge, Jhunu Chatterjee, Yousef Haik

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: In this paper, a physical method to prepare copper-nickel alloy particles in the submicron range for possible self controlled magnetic hyperthermia treatment of cancer is described. It is reported that an increase in tumor temperature decreases the tumor resistance to chemoand radiation therapies. Self controlled heating at the tumor site to avoid spot heating is managed by controlling the Curie temperature of the magnetic particles. The process described in this paper to produce the nanomagnetic particles allows for a large scale production of these particles. Methods: The process used here is mainly composed of melting of the Cu-Ni mixture and ball milling of the resulted bulk alloy. Both mechanical abrasion and continuous grinding were used to break down the bulk amount into the desired particle size. Results: It was found that the desired alloy is composed of 71% nickel and 29% copper by weight. It was observed that the coarse sand-grinded powder has a Curie temperature of 345 K and the fine ball-milled powder shows a temperature of 319 K - 320 K. Conclusion: Self regulating magnetic hyperthermia can be achieved by synthesizing nanomagnetic particles with desired Curie temperature. In this study the desired range of Curie temperatures was obtained by combination of melting and ball milling of nickel-copper alloy.

Original languageEnglish
Article number1
Pages (from-to)1-6
Number of pages6
JournalBioMagnetic Research and Technology
Volume2
DOIs
Publication statusPublished - 8 May 2004
Externally publishedYes

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Nanoparticles
Fever
Temperature
Powders
Heating
Freezing
Neoplasms
Nickel
Particle Size
Copper
Radiotherapy
Weights and Measures
nickel copper alloy

ASJC Scopus subject areas

  • Biophysics

Cite this

Physically synthesized Ni-Cu nanoparticles for magnetic hyperthermia. / Bettge, Martin; Chatterjee, Jhunu; Haik, Yousef.

In: BioMagnetic Research and Technology, Vol. 2, 1, 08.05.2004, p. 1-6.

Research output: Contribution to journalArticle

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