Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans

Engin Baturcam, Jehad Abubaker, Ali Tiss, Mohamed Abu-Farha, Abdelkrim Khadir, Fahad Al-Ghimlas, Irina Al-Khairi, Preethi Cherian, Naser Elkum, Maha Hammad, Jeena John, Sina Kavalakatt, Cynthia Lehe, Samia Warsame, Kazem Behbehani, Said Dermime, Mohammed Dehbi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.

Original languageEnglish
Article number627150
JournalMediators of Inflammation
Volume2014
DOIs
Publication statusPublished - 1 Jan 2014

Fingerprint

CCR5 Receptors
Chemokine CCL5
Adipose Tissue
Exercise
Subcutaneous Fat
Interleukin 1 Receptor Antagonist Protein
Messenger RNA
Insulin Resistance
Interleukin-6
Anti-Inflammatory Agents
Down-Regulation
Obesity
Inflammation

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans. / Baturcam, Engin; Abubaker, Jehad; Tiss, Ali; Abu-Farha, Mohamed; Khadir, Abdelkrim; Al-Ghimlas, Fahad; Al-Khairi, Irina; Cherian, Preethi; Elkum, Naser; Hammad, Maha; John, Jeena; Kavalakatt, Sina; Lehe, Cynthia; Warsame, Samia; Behbehani, Kazem; Dermime, Said; Dehbi, Mohammed.

In: Mediators of Inflammation, Vol. 2014, 627150, 01.01.2014.

Research output: Contribution to journalArticle

Baturcam, E, Abubaker, J, Tiss, A, Abu-Farha, M, Khadir, A, Al-Ghimlas, F, Al-Khairi, I, Cherian, P, Elkum, N, Hammad, M, John, J, Kavalakatt, S, Lehe, C, Warsame, S, Behbehani, K, Dermime, S & Dehbi, M 2014, 'Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans', Mediators of Inflammation, vol. 2014, 627150. https://doi.org/10.1155/2014/627150
Baturcam, Engin ; Abubaker, Jehad ; Tiss, Ali ; Abu-Farha, Mohamed ; Khadir, Abdelkrim ; Al-Ghimlas, Fahad ; Al-Khairi, Irina ; Cherian, Preethi ; Elkum, Naser ; Hammad, Maha ; John, Jeena ; Kavalakatt, Sina ; Lehe, Cynthia ; Warsame, Samia ; Behbehani, Kazem ; Dermime, Said ; Dehbi, Mohammed. / Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans. In: Mediators of Inflammation. 2014 ; Vol. 2014.
@article{92b8c6bc10c14fdbac563fd6e7c40156,
title = "Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans",
abstract = "RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.",
author = "Engin Baturcam and Jehad Abubaker and Ali Tiss and Mohamed Abu-Farha and Abdelkrim Khadir and Fahad Al-Ghimlas and Irina Al-Khairi and Preethi Cherian and Naser Elkum and Maha Hammad and Jeena John and Sina Kavalakatt and Cynthia Lehe and Samia Warsame and Kazem Behbehani and Said Dermime and Mohammed Dehbi",
year = "2014",
month = "1",
day = "1",
doi = "10.1155/2014/627150",
language = "English",
volume = "2014",
journal = "Mediators of Inflammation",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans

AU - Baturcam, Engin

AU - Abubaker, Jehad

AU - Tiss, Ali

AU - Abu-Farha, Mohamed

AU - Khadir, Abdelkrim

AU - Al-Ghimlas, Fahad

AU - Al-Khairi, Irina

AU - Cherian, Preethi

AU - Elkum, Naser

AU - Hammad, Maha

AU - John, Jeena

AU - Kavalakatt, Sina

AU - Lehe, Cynthia

AU - Warsame, Samia

AU - Behbehani, Kazem

AU - Dermime, Said

AU - Dehbi, Mohammed

PY - 2014/1/1

Y1 - 2014/1/1

N2 - RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.

AB - RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.

UR - http://www.scopus.com/inward/record.url?scp=84899900474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899900474&partnerID=8YFLogxK

U2 - 10.1155/2014/627150

DO - 10.1155/2014/627150

M3 - Article

C2 - 24895488

AN - SCOPUS:84899900474

VL - 2014

JO - Mediators of Inflammation

JF - Mediators of Inflammation

SN - 0962-9351

M1 - 627150

ER -