Phylogenetic analysis of the human thyroglobulin regions

Abdelaziz Belkadi, Caroline Jacques, Frédérique Savagner, Yves Malthièry

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Thyroglobulin is a large protein present in all vertebrates. It is synthesized in the thyrocytes and exported to lumen of the thyroid follicle, where its tyrosine residues are iodinated. The iodinated thyroglobulin is reintegrated into the cell and processed (cleaved to free its two extremities) for thyroid hormone synthesis. Thyroglobulin sequence analysis has identified four regions of the molecule: Tg1, Tg2, Tg3 and ChEL. Structural abnormalities and mutations result in different pathological consequences, depending on the thyroglobulin region affected. We carried out a bioinformatic analysis of thyroglobulin, determining the origin and the function of each region. Our results suggest that the Tg1 region acts as a binding protein on the apical membrane, the Tg2 region is involved in protein adhesion and the Tg3 region is involved in determining the three-dimensional structure of the protein. The ChEL domain is involved in thyroglobulin transport, dimerization and adhesion. The presence of repetitive domains in the Tg1, Tg2 and Tg3 regions suggests that these domains may have arisen through duplication.

Original languageEnglish
Article number3
JournalThyroid Research
Volume5
Issue number1
DOIs
Publication statusPublished - 11 Oct 2012
Externally publishedYes

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Thyroglobulin
Proteins
Dimerization
Computational Biology
Thyroid Hormones
Sequence Analysis
Tyrosine
Vertebrates
Carrier Proteins
Thyroid Gland
Extremities
Mutation
Membranes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

Phylogenetic analysis of the human thyroglobulin regions. / Belkadi, Abdelaziz; Jacques, Caroline; Savagner, Frédérique; Malthièry, Yves.

In: Thyroid Research, Vol. 5, No. 1, 3, 11.10.2012.

Research output: Contribution to journalArticle

Belkadi, Abdelaziz ; Jacques, Caroline ; Savagner, Frédérique ; Malthièry, Yves. / Phylogenetic analysis of the human thyroglobulin regions. In: Thyroid Research. 2012 ; Vol. 5, No. 1.
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