Phosphorylation of serine 10 in histone H3, what for?

Claude Prigent, Stefan Dimitrov

Research output: Contribution to journalArticle

311 Citations (Scopus)

Abstract

Eukaryotic cells must possess mechanisms for condensing and decondensing chromatin. Chromatin condensation is particularly evident during mitosis and cell death induced by apoptosis, whereas chromatin decondensation is necessary for replication, repair, recombination and transcription. Histones are among the numerous DNA-binding proteins that control the level of DNA condensation, and post-translational modification of histone tails plays a critical role in the dynamic condensation/decondensation that occurs during the cell cycle. Phosphorylation of Ser10 in the tails of histone H3 has been extensively studied in many organisms. Interestingly, this modification is involved in both transcription and cell division, two events requiring opposite alterations in the degree of chromatin compaction. How does one and the same modification of histone H3 fulfil such roles? For instance, in interphase, phosphorylation of H3 correlates with chromatin relaxation and gene expression, whereas in mitosis it correlates with chromosome condensation. What is the kinase and under what circumstances does Ser10 becomes phosphorylated? Most importantly, what are the consequences of phosphorylation of this residue?

Original languageEnglish
Pages (from-to)3677-3685
Number of pages9
JournalJournal of Cell Science
Volume116
Issue number18
DOIs
Publication statusPublished - 15 Sep 2003
Externally publishedYes

Fingerprint

Histones
Serine
Chromatin
Phosphorylation
Mitosis
Recombinational DNA Repair
Interphase
DNA-Binding Proteins
Eukaryotic Cells
Post Translational Protein Processing
Cell Division
Cell Cycle
Cell Death
Phosphotransferases
Chromosomes
Apoptosis
Gene Expression
DNA

Keywords

  • Chromatin
  • Histone H3
  • Mitosis
  • Phosphorylation
  • Serine 10

ASJC Scopus subject areas

  • Cell Biology

Cite this

Phosphorylation of serine 10 in histone H3, what for? / Prigent, Claude; Dimitrov, Stefan.

In: Journal of Cell Science, Vol. 116, No. 18, 15.09.2003, p. 3677-3685.

Research output: Contribution to journalArticle

Prigent, Claude ; Dimitrov, Stefan. / Phosphorylation of serine 10 in histone H3, what for?. In: Journal of Cell Science. 2003 ; Vol. 116, No. 18. pp. 3677-3685.
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