Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes

John Walmsley, Gary Mirams, Maya Bahoshy, Christian Bollensdorff, Blanca Rodriguez, Kevin Burrage

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Abstract

Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beatto- beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells originating from the same region of the same heart. However, current mathematical models of ventricular AP fail to replicate the temporal and cell-to-cell variability in AP observed experimentally. In this study, we propose a novel mathematical framework for the development of phenomenological AP models capable of capturing cell-to-cell and temporal variabilty in cardiac APs. A novel stochastic phenomenological model of the AP is developed, based on the deterministic Bueno- Orovio/Fenton model. Experimental recordings of AP are fit to the model to produce AP models of individual cells from the apex and the base of the guinea-pig ventricles. Our results show that the phenomenological model is able to capture the considerable differences in AP recorded from isolated cells originating from the location. We demonstrate the closeness of fit to the available experimental data which may be achieved using a phenomenological model, and also demonstrate the ability of the stochastic form of the model to capture the observed beat-to-beat variablity in action potential duration.

Original languageEnglish
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages1457-1460
Number of pages4
DOIs
Publication statusPublished - 1 Dec 2010
Externally publishedYes
Event2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
Duration: 31 Aug 20104 Sep 2010

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
CountryArgentina
CityBuenos Aires
Period31/8/104/9/10

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Stochastic models
Mathematical models

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Walmsley, J., Mirams, G., Bahoshy, M., Bollensdorff, C., Rodriguez, B., & Burrage, K. (2010). Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (pp. 1457-1460). [5626858] https://doi.org/10.1109/IEMBS.2010.5626858

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. / Walmsley, John; Mirams, Gary; Bahoshy, Maya; Bollensdorff, Christian; Rodriguez, Blanca; Burrage, Kevin.

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1457-1460 5626858.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Walmsley, J, Mirams, G, Bahoshy, M, Bollensdorff, C, Rodriguez, B & Burrage, K 2010, Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10., 5626858, pp. 1457-1460, 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina, 31/8/10. https://doi.org/10.1109/IEMBS.2010.5626858
Walmsley J, Mirams G, Bahoshy M, Bollensdorff C, Rodriguez B, Burrage K. Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1457-1460. 5626858 https://doi.org/10.1109/IEMBS.2010.5626858
Walmsley, John ; Mirams, Gary ; Bahoshy, Maya ; Bollensdorff, Christian ; Rodriguez, Blanca ; Burrage, Kevin. / Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated guinea pig ventricular myocytes. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. pp. 1457-1460
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