Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

Ronald G. Crystal, Edward Hirschowitz, Michael Lieberman, John Daly, Elias Kazam, Claudia Henschke, David Yankelevitz, Nancy Kemeny, Roy Silverstein, Akihiko Ohwada, Thomas Russi, Andrea Mastrangeli, Abraham Sanders, Joseph Cooke, Ben Gary Harvey

Research output: Contribution to journalArticle

119 Citations (Scopus)
Original languageEnglish
Pages (from-to)985-1001
Number of pages17
JournalHuman gene therapy
Volume8
Issue number8
DOIs
Publication statusPublished - 20 May 1997

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Crystal, R. G., Hirschowitz, E., Lieberman, M., Daly, J., Kazam, E., Henschke, C., Yankelevitz, D., Kemeny, N., Silverstein, R., Ohwada, A., Russi, T., Mastrangeli, A., Sanders, A., Cooke, J., & Harvey, B. G. (1997). Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Human gene therapy, 8(8), 985-1001. https://doi.org/10.1089/hum.1997.8.8-985