Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

Ronald Crystal, Edward Hirschowitz, Michael Lieberman, John Daly, Elias Kazam, Claudia Henschke, David Yankelevitz, Nancy Kemeny, Roy Silverstein, Akihiko Ohwada, Thomas Russi, Andrea Mastrangeli, Abraham Sanders, Joseph Cooke, Ben Gary Harvey

Research output: Contribution to journalArticle

118 Citations (Scopus)
Original languageEnglish
Pages (from-to)985-1001
Number of pages17
JournalHuman Gene Therapy
Volume8
Issue number8
Publication statusPublished - 20 May 1997
Externally publishedYes

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Nucleoside Deaminases
Cytosine Deaminase
Flucytosine
Antimetabolites
Genetic Vectors
Prodrugs
Liver Neoplasms
Virus Replication
Adenoviridae
Genetic Therapy
Colonic Neoplasms
Oral Administration
Colon
Escherichia coli
Carcinoma
Liver
Genes
E coli codA protein

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. / Crystal, Ronald; Hirschowitz, Edward; Lieberman, Michael; Daly, John; Kazam, Elias; Henschke, Claudia; Yankelevitz, David; Kemeny, Nancy; Silverstein, Roy; Ohwada, Akihiko; Russi, Thomas; Mastrangeli, Andrea; Sanders, Abraham; Cooke, Joseph; Harvey, Ben Gary.

In: Human Gene Therapy, Vol. 8, No. 8, 20.05.1997, p. 985-1001.

Research output: Contribution to journalArticle

Crystal, R, Hirschowitz, E, Lieberman, M, Daly, J, Kazam, E, Henschke, C, Yankelevitz, D, Kemeny, N, Silverstein, R, Ohwada, A, Russi, T, Mastrangeli, A, Sanders, A, Cooke, J & Harvey, BG 1997, 'Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine', Human Gene Therapy, vol. 8, no. 8, pp. 985-1001.
Crystal, Ronald ; Hirschowitz, Edward ; Lieberman, Michael ; Daly, John ; Kazam, Elias ; Henschke, Claudia ; Yankelevitz, David ; Kemeny, Nancy ; Silverstein, Roy ; Ohwada, Akihiko ; Russi, Thomas ; Mastrangeli, Andrea ; Sanders, Abraham ; Cooke, Joseph ; Harvey, Ben Gary. / Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. In: Human Gene Therapy. 1997 ; Vol. 8, No. 8. pp. 985-1001.
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AU - Kemeny, Nancy

AU - Silverstein, Roy

AU - Ohwada, Akihiko

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AU - Mastrangeli, Andrea

AU - Sanders, Abraham

AU - Cooke, Joseph

AU - Harvey, Ben Gary

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