Pharmacological studies of smooth muscle from Dahl salt-sensitive and salt-resistant rats

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The pharmacological properties of various isolated smooth muscle preparations from the Dahl strain of hypertensive rats were studied. The Dahl salt-sensitive (DS) rat was allowed to develop hypertension by increasing the dietary sodium from 0.4 to 4.0 or 8.0%. The Dahl salt-resistant (DR) rat remained normotensive on the same diet. The preparations studied were the thoracic aorta, tail artery, portal vein, anococcygeus, and the perfused mesenteric bed. The noradrenaline mean effective doses (ED50) either in the absence or presence of cocaine, were similar for tissues obtained from hypertensive DS or normotensive DR. The reactivities of the isolated perfused mesenteric preparation to noradrenaline, serotonin, and phenylephrine were similar in DS and DR. The ED50 for the relaxing effects of papaverine in noradrenaline-precontracted aorta was similar for tissues from DS and DR and the profile for the washout of noradrenaline-precontracted aorta with Krebs (with or without papaverine) was also similar in DS and DR. The results of this study were compared with similar studies performed using other models of hypertension. It is concluded that vascular changes are unlikely to play a major role in the etiology of hypertension in the Dahl rat model of essential hypertension.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalCanadian Journal of Physiology and Pharmacology
Volume62
Issue number1
Publication statusPublished - 1984
Externally publishedYes

Fingerprint

Smooth Muscle
Salts
Pharmacology
Inbred Dahl Rats
Norepinephrine
Papaverine
Hypertension
Aorta
Dietary Sodium
Phenylephrine
Portal Vein
Thoracic Aorta
Cocaine
Blood Vessels
Tail
Serotonin
Arteries
Diet

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

@article{dee63d7f45e84689b5ac2b64d08d248c,
title = "Pharmacological studies of smooth muscle from Dahl salt-sensitive and salt-resistant rats",
abstract = "The pharmacological properties of various isolated smooth muscle preparations from the Dahl strain of hypertensive rats were studied. The Dahl salt-sensitive (DS) rat was allowed to develop hypertension by increasing the dietary sodium from 0.4 to 4.0 or 8.0{\%}. The Dahl salt-resistant (DR) rat remained normotensive on the same diet. The preparations studied were the thoracic aorta, tail artery, portal vein, anococcygeus, and the perfused mesenteric bed. The noradrenaline mean effective doses (ED50) either in the absence or presence of cocaine, were similar for tissues obtained from hypertensive DS or normotensive DR. The reactivities of the isolated perfused mesenteric preparation to noradrenaline, serotonin, and phenylephrine were similar in DS and DR. The ED50 for the relaxing effects of papaverine in noradrenaline-precontracted aorta was similar for tissues from DS and DR and the profile for the washout of noradrenaline-precontracted aorta with Krebs (with or without papaverine) was also similar in DS and DR. The results of this study were compared with similar studies performed using other models of hypertension. It is concluded that vascular changes are unlikely to play a major role in the etiology of hypertension in the Dahl rat model of essential hypertension.",
author = "I. Laher and Christopher Triggle",
year = "1984",
language = "English",
volume = "62",
pages = "101--104",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "1",

}

TY - JOUR

T1 - Pharmacological studies of smooth muscle from Dahl salt-sensitive and salt-resistant rats

AU - Laher, I.

AU - Triggle, Christopher

PY - 1984

Y1 - 1984

N2 - The pharmacological properties of various isolated smooth muscle preparations from the Dahl strain of hypertensive rats were studied. The Dahl salt-sensitive (DS) rat was allowed to develop hypertension by increasing the dietary sodium from 0.4 to 4.0 or 8.0%. The Dahl salt-resistant (DR) rat remained normotensive on the same diet. The preparations studied were the thoracic aorta, tail artery, portal vein, anococcygeus, and the perfused mesenteric bed. The noradrenaline mean effective doses (ED50) either in the absence or presence of cocaine, were similar for tissues obtained from hypertensive DS or normotensive DR. The reactivities of the isolated perfused mesenteric preparation to noradrenaline, serotonin, and phenylephrine were similar in DS and DR. The ED50 for the relaxing effects of papaverine in noradrenaline-precontracted aorta was similar for tissues from DS and DR and the profile for the washout of noradrenaline-precontracted aorta with Krebs (with or without papaverine) was also similar in DS and DR. The results of this study were compared with similar studies performed using other models of hypertension. It is concluded that vascular changes are unlikely to play a major role in the etiology of hypertension in the Dahl rat model of essential hypertension.

AB - The pharmacological properties of various isolated smooth muscle preparations from the Dahl strain of hypertensive rats were studied. The Dahl salt-sensitive (DS) rat was allowed to develop hypertension by increasing the dietary sodium from 0.4 to 4.0 or 8.0%. The Dahl salt-resistant (DR) rat remained normotensive on the same diet. The preparations studied were the thoracic aorta, tail artery, portal vein, anococcygeus, and the perfused mesenteric bed. The noradrenaline mean effective doses (ED50) either in the absence or presence of cocaine, were similar for tissues obtained from hypertensive DS or normotensive DR. The reactivities of the isolated perfused mesenteric preparation to noradrenaline, serotonin, and phenylephrine were similar in DS and DR. The ED50 for the relaxing effects of papaverine in noradrenaline-precontracted aorta was similar for tissues from DS and DR and the profile for the washout of noradrenaline-precontracted aorta with Krebs (with or without papaverine) was also similar in DS and DR. The results of this study were compared with similar studies performed using other models of hypertension. It is concluded that vascular changes are unlikely to play a major role in the etiology of hypertension in the Dahl rat model of essential hypertension.

UR - http://www.scopus.com/inward/record.url?scp=0021348313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021348313&partnerID=8YFLogxK

M3 - Article

VL - 62

SP - 101

EP - 104

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 1

ER -