Pharmacogenomics in the development and characterization of atheroprotective drugs

Efi Valanti, Alexandros Tsompanidis, Despina Sanoudou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Atherosclerosis is the main cause of cardiovascular disease (CVD) and can lead to stroke, myocardial infarction, and death. The clinically available atheroprotective drugs aim mainly at reducing the levels of circulating low-density lipoprotein (LDL), increasing high-density lipoprotein (HDL), and attenuating inflammation. However, the cardiovascular risk remains high, along with morbidity, mortality, and incidence of adverse drug events. Pharmacogenomics is increasingly contributing towards the characterization of existing ath­eroprotective drugs, the evaluation of novel ones, and the identification of promising, unexplored thera­peutic targets, at the global molecular pathway level. This chapter presents highlights of pharmacogenomics investigations and discoveries that have contributed towards the elucidation of pharmacological atheropro-tection, while opening the way to new therapeutic approaches.

Original languageEnglish
Pages (from-to)259-300
Number of pages42
JournalMethods in Molecular Biology
Volume1175
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Keywords

  • Adverse effects
  • Atherosclerosis
  • Pharmacogenomics
  • Therapeutic mechanisms
  • Therapeutic targeting

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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