Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

Christian Doerig, Caroline Doerig, Paul Horrocks, Joseph Coyle, Jane Carlton, Ali Sultan, David Arnot, Richard Carter

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalMolecular and Biochemical Parasitology
Volume70
Issue number1-2
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Cyclin-Dependent Kinase 2
Plasmodium falciparum
Genes
Chromosomes, Human, Pair 4
Oligonucleotides
Vertebrates
Messenger RNA
Growth

Keywords

  • Cell-cycle control
  • p58
  • Plasmodium falciparum
  • Protein kinase
  • Sexual differentiation

ASJC Scopus subject areas

  • Parasitology
  • Molecular Biology

Cite this

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum. / Doerig, Christian; Doerig, Caroline; Horrocks, Paul; Coyle, Joseph; Carlton, Jane; Sultan, Ali; Arnot, David; Carter, Richard.

In: Molecular and Biochemical Parasitology, Vol. 70, No. 1-2, 1995, p. 167-174.

Research output: Contribution to journalArticle

Doerig, Christian ; Doerig, Caroline ; Horrocks, Paul ; Coyle, Joseph ; Carlton, Jane ; Sultan, Ali ; Arnot, David ; Carter, Richard. / Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum. In: Molecular and Biochemical Parasitology. 1995 ; Vol. 70, No. 1-2. pp. 167-174.
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AU - Sultan, Ali

AU - Arnot, David

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