PET scan before CABG in diabetes

Hesham Hegazy, Ayman Refaei, Azza Assedique, Shukri Alsaif, Mayada Taha, Mostafa Refaei, Naser Elkum, Hamed Alomran, Zohair Al-Halees

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and objectives: Since the role of positron emission tomography (PET) scanning in diabetes is not clear, this study sought to assess the usefulness of PET scanning for viability in this patient group. Methods: Forty-four per cent insulin-treated, and 56% non-insulin-treated diabetic patients with severely impaired left ventricular function (LVEF 29±9%) underwent first coronary artery bypass grafting (CABG). Pre-operative viability was assessed by PET scan. Results: Eighty-two per cent of patients received ≥ 3 grafts. Twenty-seven patients were discharged home and followed for a mean 3.5±1.6 years. Postoperative LVEF improved to 40±9 (p<0.0001). Multiple regression analysis indicated that the only variable that predicted improvement in global LV function was presence of hibernating segments at PET scan. The single variable that predicted deterioration of LVEF was the number of segments with reduced perfusion and metabolism at PET scan. Conclusion: PET scan is an accurate tool for prediction of global left ventricular function recovery following CABG in people with diabetes.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalBritish Journal of Diabetes and Vascular Disease
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Fingerprint

Coronary Artery Bypass
Positron-Emission Tomography
Left Ventricular Function
Perfusion
Regression Analysis
Insulin
Transplants

Keywords

  • Bypass surgery
  • Coronary artery disease
  • Diabetes
  • Hibernating myocardium
  • Impaired left ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Hegazy, H., Refaei, A., Assedique, A., Alsaif, S., Taha, M., Refaei, M., ... Al-Halees, Z. (2007). PET scan before CABG in diabetes. British Journal of Diabetes and Vascular Disease, 7(1), 32-37. https://doi.org/10.1177/14746514070070010601

PET scan before CABG in diabetes. / Hegazy, Hesham; Refaei, Ayman; Assedique, Azza; Alsaif, Shukri; Taha, Mayada; Refaei, Mostafa; Elkum, Naser; Alomran, Hamed; Al-Halees, Zohair.

In: British Journal of Diabetes and Vascular Disease, Vol. 7, No. 1, 01.2007, p. 32-37.

Research output: Contribution to journalArticle

Hegazy, H, Refaei, A, Assedique, A, Alsaif, S, Taha, M, Refaei, M, Elkum, N, Alomran, H & Al-Halees, Z 2007, 'PET scan before CABG in diabetes', British Journal of Diabetes and Vascular Disease, vol. 7, no. 1, pp. 32-37. https://doi.org/10.1177/14746514070070010601
Hegazy H, Refaei A, Assedique A, Alsaif S, Taha M, Refaei M et al. PET scan before CABG in diabetes. British Journal of Diabetes and Vascular Disease. 2007 Jan;7(1):32-37. https://doi.org/10.1177/14746514070070010601
Hegazy, Hesham ; Refaei, Ayman ; Assedique, Azza ; Alsaif, Shukri ; Taha, Mayada ; Refaei, Mostafa ; Elkum, Naser ; Alomran, Hamed ; Al-Halees, Zohair. / PET scan before CABG in diabetes. In: British Journal of Diabetes and Vascular Disease. 2007 ; Vol. 7, No. 1. pp. 32-37.
@article{4edd6e95be834d788ee291a50b8e4b20,
title = "PET scan before CABG in diabetes",
abstract = "Background and objectives: Since the role of positron emission tomography (PET) scanning in diabetes is not clear, this study sought to assess the usefulness of PET scanning for viability in this patient group. Methods: Forty-four per cent insulin-treated, and 56{\%} non-insulin-treated diabetic patients with severely impaired left ventricular function (LVEF 29±9{\%}) underwent first coronary artery bypass grafting (CABG). Pre-operative viability was assessed by PET scan. Results: Eighty-two per cent of patients received ≥ 3 grafts. Twenty-seven patients were discharged home and followed for a mean 3.5±1.6 years. Postoperative LVEF improved to 40±9 (p<0.0001). Multiple regression analysis indicated that the only variable that predicted improvement in global LV function was presence of hibernating segments at PET scan. The single variable that predicted deterioration of LVEF was the number of segments with reduced perfusion and metabolism at PET scan. Conclusion: PET scan is an accurate tool for prediction of global left ventricular function recovery following CABG in people with diabetes.",
keywords = "Bypass surgery, Coronary artery disease, Diabetes, Hibernating myocardium, Impaired left ventricular function",
author = "Hesham Hegazy and Ayman Refaei and Azza Assedique and Shukri Alsaif and Mayada Taha and Mostafa Refaei and Naser Elkum and Hamed Alomran and Zohair Al-Halees",
year = "2007",
month = "1",
doi = "10.1177/14746514070070010601",
language = "English",
volume = "7",
pages = "32--37",
journal = "British Journal of Diabetes and Vascular Disease",
issn = "1474-6514",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - PET scan before CABG in diabetes

AU - Hegazy, Hesham

AU - Refaei, Ayman

AU - Assedique, Azza

AU - Alsaif, Shukri

AU - Taha, Mayada

AU - Refaei, Mostafa

AU - Elkum, Naser

AU - Alomran, Hamed

AU - Al-Halees, Zohair

PY - 2007/1

Y1 - 2007/1

N2 - Background and objectives: Since the role of positron emission tomography (PET) scanning in diabetes is not clear, this study sought to assess the usefulness of PET scanning for viability in this patient group. Methods: Forty-four per cent insulin-treated, and 56% non-insulin-treated diabetic patients with severely impaired left ventricular function (LVEF 29±9%) underwent first coronary artery bypass grafting (CABG). Pre-operative viability was assessed by PET scan. Results: Eighty-two per cent of patients received ≥ 3 grafts. Twenty-seven patients were discharged home and followed for a mean 3.5±1.6 years. Postoperative LVEF improved to 40±9 (p<0.0001). Multiple regression analysis indicated that the only variable that predicted improvement in global LV function was presence of hibernating segments at PET scan. The single variable that predicted deterioration of LVEF was the number of segments with reduced perfusion and metabolism at PET scan. Conclusion: PET scan is an accurate tool for prediction of global left ventricular function recovery following CABG in people with diabetes.

AB - Background and objectives: Since the role of positron emission tomography (PET) scanning in diabetes is not clear, this study sought to assess the usefulness of PET scanning for viability in this patient group. Methods: Forty-four per cent insulin-treated, and 56% non-insulin-treated diabetic patients with severely impaired left ventricular function (LVEF 29±9%) underwent first coronary artery bypass grafting (CABG). Pre-operative viability was assessed by PET scan. Results: Eighty-two per cent of patients received ≥ 3 grafts. Twenty-seven patients were discharged home and followed for a mean 3.5±1.6 years. Postoperative LVEF improved to 40±9 (p<0.0001). Multiple regression analysis indicated that the only variable that predicted improvement in global LV function was presence of hibernating segments at PET scan. The single variable that predicted deterioration of LVEF was the number of segments with reduced perfusion and metabolism at PET scan. Conclusion: PET scan is an accurate tool for prediction of global left ventricular function recovery following CABG in people with diabetes.

KW - Bypass surgery

KW - Coronary artery disease

KW - Diabetes

KW - Hibernating myocardium

KW - Impaired left ventricular function

UR - http://www.scopus.com/inward/record.url?scp=33947279964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947279964&partnerID=8YFLogxK

U2 - 10.1177/14746514070070010601

DO - 10.1177/14746514070070010601

M3 - Article

VL - 7

SP - 32

EP - 37

JO - British Journal of Diabetes and Vascular Disease

JF - British Journal of Diabetes and Vascular Disease

SN - 1474-6514

IS - 1

ER -