Peritoneal inflammation - A microenvironment for epithelial ovarian cancer (EOC)

Ralph S. Freedman, Michael Deavers, Jinsong Liu, Ena Wang

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

Epithelial ovarian cancer (EOC) is a significant cause of cancer related morbidity and mortality in women. Preferential involvement of peritoneal structures contributes to the overall poor outcome in EOC patients. Advances in biotechnology, such as cDNA microarray, are a product of the Human Genome Project and are beginning to provide fresh opportunities to understand the biology of EOC. In particular, it is now possible to examine in depth, at the molecular level, the complex relationship between the tumor itself and its surrounding microenvironment. This review focuses on the anatomy, physiology, and current immunobiologic research of peritoneal structures, and addresses certain potentially useful animal models. Changes in both the inflammatory and non-inflammatory cell compartments, as well as alterations to the extracellular matrix, appear to be signal events that contribute to the remodeling effects of the peritoneal stroma and surface epithelial cells on tumor growth and spread. These alterations may involve a number of proteins, including cytokines, chemokines, growth factors, either membrane or non-membrane bound, and integrins. Interactions between these molecules and molecular structures within the extracellular matrix, such as collagens and the proteoglycans, may contribute to a peritoneal mesothelial surface and stromal environment that is conducive to tumor cell proliferation and invasion. These alterations need to be examined and defined as possible prosnosticators and as therapeutic or diagnostic targets.

Original languageEnglish
Article number23
JournalJournal of Translational Medicine
Volume2
DOIs
Publication statusPublished - 25 Jun 2004
Externally publishedYes

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Tumors
Inflammation
Extracellular Matrix
Neoplasms
Physiology
Cell proliferation
Proteoglycans
Biotechnology
Microarrays
Human Genome Project
Chemokines
Integrins
Molecular structure
Intercellular Signaling Peptides and Proteins
Animals
Collagen
Complementary DNA
Genes
Oligonucleotide Array Sequence Analysis
Molecular Structure

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Peritoneal inflammation - A microenvironment for epithelial ovarian cancer (EOC). / Freedman, Ralph S.; Deavers, Michael; Liu, Jinsong; Wang, Ena.

In: Journal of Translational Medicine, Vol. 2, 23, 25.06.2004.

Research output: Contribution to journalReview article

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