Peripheral neuropathy in patients with multiple sclerosis

Adnan Khan, Saadat Kamran, Georgios Ponirakis, Naveed Akhtar, Rabia Khan, Pooja George, Blessy M. Babu, Faiza M. Ibrahim, Ioannis N. Petropoulos, Beatriz G. Canibano, Stacy S. Wilins, Dirk Deleu, Ashfaq Shuaib, Rayaz Malik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. Methods: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). Results: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). Conclusions: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.

Original languageEnglish
Article number0193270
JournalPLoS One
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Fingerprint

peripheral nervous system diseases
sclerosis
Peripheral Nervous System Diseases
Multiple Sclerosis
Skin
Vibration
vibration
Neuralgia
Foot
pain
hands
Hand
relapse
Recurrence
mirfentanil

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Peripheral neuropathy in patients with multiple sclerosis. / Khan, Adnan; Kamran, Saadat; Ponirakis, Georgios; Akhtar, Naveed; Khan, Rabia; George, Pooja; Babu, Blessy M.; Ibrahim, Faiza M.; Petropoulos, Ioannis N.; Canibano, Beatriz G.; Wilins, Stacy S.; Deleu, Dirk; Shuaib, Ashfaq; Malik, Rayaz.

In: PLoS One, Vol. 13, No. 3, 0193270, 01.03.2018.

Research output: Contribution to journalArticle

Khan, A, Kamran, S, Ponirakis, G, Akhtar, N, Khan, R, George, P, Babu, BM, Ibrahim, FM, Petropoulos, IN, Canibano, BG, Wilins, SS, Deleu, D, Shuaib, A & Malik, R 2018, 'Peripheral neuropathy in patients with multiple sclerosis', PLoS One, vol. 13, no. 3, 0193270. https://doi.org/10.1371/journal.pone.0193270
Khan, Adnan ; Kamran, Saadat ; Ponirakis, Georgios ; Akhtar, Naveed ; Khan, Rabia ; George, Pooja ; Babu, Blessy M. ; Ibrahim, Faiza M. ; Petropoulos, Ioannis N. ; Canibano, Beatriz G. ; Wilins, Stacy S. ; Deleu, Dirk ; Shuaib, Ashfaq ; Malik, Rayaz. / Peripheral neuropathy in patients with multiple sclerosis. In: PLoS One. 2018 ; Vol. 13, No. 3.
@article{6b5c3967950b44d6abb066f50cfbe30f,
title = "Peripheral neuropathy in patients with multiple sclerosis",
abstract = "Objectives: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. Methods: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). Results: Patients with MS had a higher DN4 score (p < 0.001) with 14{\%} fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32{\%} of MS patients) and hands (30{\%} of MS patients) were lower, and DN4 (77{\%} of MS patients) and VPT (64{\%} of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). Conclusions: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.",
author = "Adnan Khan and Saadat Kamran and Georgios Ponirakis and Naveed Akhtar and Rabia Khan and Pooja George and Babu, {Blessy M.} and Ibrahim, {Faiza M.} and Petropoulos, {Ioannis N.} and Canibano, {Beatriz G.} and Wilins, {Stacy S.} and Dirk Deleu and Ashfaq Shuaib and Rayaz Malik",
year = "2018",
month = "3",
day = "1",
doi = "10.1371/journal.pone.0193270",
language = "English",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Peripheral neuropathy in patients with multiple sclerosis

AU - Khan, Adnan

AU - Kamran, Saadat

AU - Ponirakis, Georgios

AU - Akhtar, Naveed

AU - Khan, Rabia

AU - George, Pooja

AU - Babu, Blessy M.

AU - Ibrahim, Faiza M.

AU - Petropoulos, Ioannis N.

AU - Canibano, Beatriz G.

AU - Wilins, Stacy S.

AU - Deleu, Dirk

AU - Shuaib, Ashfaq

AU - Malik, Rayaz

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Objectives: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. Methods: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). Results: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). Conclusions: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.

AB - Objectives: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. Methods: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). Results: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). Conclusions: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.

UR - http://www.scopus.com/inward/record.url?scp=85043326598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043326598&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0193270

DO - 10.1371/journal.pone.0193270

M3 - Article

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - 0193270

ER -