Peripheral neuropathy in patients with multiple sclerosis

Adnan Khan, Saadat Kamran, Georgios Ponirakis, Naveed Akhtar, Rabia Khan, Pooja George, Blessy M. Babu, Faiza M. Ibrahim, Ioannis N. Petropoulos, Beatriz G. Canibano, Stacy S. Wilins, Dirk Deleu, Ashfaq Shuaib, Rayaz Malik

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5 Citations (Scopus)


Objectives: To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. Methods: 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). Results: Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). Conclusions: Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.

Original languageEnglish
Article number0193270
JournalPLoS One
Issue number3
Publication statusPublished - 1 Mar 2018


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Khan, A., Kamran, S., Ponirakis, G., Akhtar, N., Khan, R., George, P., Babu, B. M., Ibrahim, F. M., Petropoulos, I. N., Canibano, B. G., Wilins, S. S., Deleu, D., Shuaib, A., & Malik, R. (2018). Peripheral neuropathy in patients with multiple sclerosis. PLoS One, 13(3), [0193270].